Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Pisa, Italy.
Pulmonary Environmental Epidemiology Unit, CNR Institute of Clinical Physiology, Pisa, Italy.
Environ Res. 2022 Apr 15;206:112428. doi: 10.1016/j.envres.2021.112428. Epub 2021 Nov 24.
the built environment in urban areas may have side effects on children's respiratory health, whilst less is known for adulthood.
to assess the association between increasing exposure to grey spaces and allergic status in an adult general population sample.
2070 subjects (age range 15-84 yrs), living in Pisa/Cascina, Italy, were investigated in 1991-93 through a questionnaire on health status and risk factors, skin prick test (SPT), serum Immunoglobulins E (IgE), and serum antibodies to benzo(a)pyrene diol epoxide (BPDE)-DNA adducts. Land-cover exposure within a 1000 m buffer from each subject's home address was assessed through the CORINE Land Cover program (CLC 1990) within the FP7/HEALS project (2013-2018). Participants' residential addresses were geocoded and the proportion of surrounding grey spaces was calculated. Through logistic regression models, adjusting for potential confounding factors, the effect of a 10% increase in grey spaces exposure on allergic biomarkers/conditions was assessed; the relationship with serum antibodies to BPDE-DNA adducts positivity was also analyzed.
A 10% increase in grey spaces coverage was associated with a higher probability of having SPT positivity (OR 1.07, 95% CI 1.02-1.13), seasonal SPT positivity (OR 1.12, 1.05-1.19), polysensitization (OR 1.11, 1.04-1.19), allergic rhinitis (OR 1.10, 1.04-1.17), co-presence of SPT positivity and asthma/allergic rhinitis (OR 1.16, 1.08-1.25), asthma/allergic rhinitis (OR 1.06, 1.00-1.12), presence of serum antibodies to BPDE-DNA adducts positivity (OR 1.07, 1.01-1.14).
grey spaces have adverse effects on allergic status and are related to a biomarker of polycyclic aromatic hydrocarbons exposure in adulthood. Thus, they may be used as a proxy of urban environmental exposure.
城市环境中的人为环境可能对儿童的呼吸健康产生副作用，而成年人的情况则知之甚少。
评估在成人一般人群样本中，接触灰色空间增加与过敏状态之间的关联。
1991-93 年，意大利比萨/卡斯奇纳的 2070 名年龄在 15-84 岁之间的受试者通过健康状况和危险因素问卷、皮肤点刺试验 (SPT)、血清免疫球蛋白 E (IgE) 和血清苯并 (a) 芘二醇环氧化物 (BPDE)-DNA 加合物抗体进行了调查。通过 FP7/HEALS 项目（2013-2018 年）中的 CORINE 土地覆盖计划（CLC 1990），评估了每个受试者家庭住址 1000 米缓冲区内地貌覆盖的暴露情况。通过地理编码参与者的居住地址，并计算周围灰色空间的比例。通过逻辑回归模型，调整潜在的混杂因素，评估灰色空间暴露增加 10%对过敏生物标志物/状况的影响；还分析了与血清 BPDE-DNA 加合物抗体阳性的关系。
灰色空间覆盖率增加 10%与 SPT 阳性的可能性增加相关（OR 1.07，95%CI 1.02-1.13）、季节性 SPT 阳性（OR 1.12，1.05-1.19）、多敏化（OR 1.11，1.04-1.19）、过敏性鼻炎（OR 1.10，1.04-1.17）、SPT 阳性和哮喘/过敏性鼻炎同时存在（OR 1.16，1.08-1.25）、哮喘/过敏性鼻炎（OR 1.06，1.00-1.12）、血清 BPDE-DNA 加合物抗体阳性（OR 1.07，1.01-1.14）。
灰色空间对过敏状态有不利影响，并与成年人多环芳烃暴露的生物标志物有关。因此，它们可以用作城市环境暴露的替代物。
