Han Hui, Dou Jinming, Hou Qingqing, Wang Huanjun
School of Health, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Department of Pediatrics, the 960 Hospital of the People's Liberation Army, Jinan, Shandong, China.
J Cardiovasc Pharmacol. 2022 Mar 1;79(3):254-263. doi: 10.1097/FJC.0000000000001178.
Molecular circadian clocks exist in almost all cells of the organism and operate for approximately 24 hours, maintain the normal physiological and behavioral body processes, and regulate metabolism of many cells related to a variety of disease states. Circadian rhythms regulate metabolism, mainly including neurotransmitters, hormones, amino acids, and lipids. Circadian misalignment is related to metabolic syndromes, such as obesity, diabetes, and hypertension, which have reached an alarming level in modern society. We reviewed the mechanism of the circadian clock and the interaction between circadian rhythm and metabolism, as well as circadian rhythm disturbance on the metabolism of hypertension, obesity, and diabetes. Finally, we discuss how to use the circadian rhythm to prevent diseases. Thus, this review is a micro-to-macro discussion from the perspective of circadian rhythm and aims to provide basic ideas for circadian rhythm research and disease therapies.
分子生物钟存在于生物体的几乎所有细胞中，运行约24小时，维持身体正常的生理和行为过程，并调节与多种疾病状态相关的许多细胞的代谢。昼夜节律调节代谢，主要包括神经递质、激素、氨基酸和脂质。昼夜节律失调与代谢综合征有关，如肥胖、糖尿病和高血压，这些在现代社会已达到惊人的程度。我们综述了生物钟的机制、昼夜节律与代谢之间的相互作用，以及昼夜节律紊乱对高血压、肥胖和糖尿病代谢的影响。最后，我们讨论了如何利用昼夜节律预防疾病。因此，本综述从昼夜节律的角度进行了微观到宏观的讨论，旨在为昼夜节律研究和疾病治疗提供基本思路。
