Wilborn Doris, Kottner Jan, Hillmann Kathrin, Xu Sa, Konietschke Frank, Blume-Peytavi Ulrike
Clinical Research Center for Hair and Skin Science, Department of Dermatology, Venereology and Allergology, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany.
Institute of Clinical Nursing Science, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin 10117, Germany.
Dermatol Res Pract. 2021 Nov 17;2021:4163705. doi: 10.1155/2021/4163705. eCollection 2021.
Pregnancy leads to several skin changes, but evidence about structural and functional skin changes is scarce. Findings on skin structure and function in children in their first year reveal rapid skin maturation, but evidence indicates that in particular, water holding and transport mechanisms are different from adults. Important questions include whether maternal cutaneous properties predict infant skin condition, and if so, how. This is especially relevant for the skin's microbiome because it closely interacts with the host and is assumed to play a role in many skin diseases. Therefore, the study objective is to explore characteristics of skin and hair of pregnant women and their newborns during pregnancy and in the first six months after delivery and their associations.
The study has an observational longitudinal design. We are recruiting pregnant females between 18 and 45 years using advertisement campaigns in waiting areas of gynecologists and hospital's outpatient services. A final sample size of = 100 women is the target. We perform noninvasive, standardized skin, hair, and skin microbiome measurements. We establish the baseline visit during pregnancy until at the latest four weeks before delivery. We schedule follow-up visits four weeks and six months after birth for mothers and their newborns. We will calculate descriptive statistical methods using frequencies and associations over time depending on scale levels of the measurements. . The majority of previous studies that have investigated infants' skin microbiome and its associations used cross-sectional designs and focused on selected characteristics in small samples. In our longitudinal study, we will characterize a broad range of individual and environmental characteristics of mothers and their newborns to evaluate interrelationships with skin parameters and their changes over time. Considering the combination of these multiple variables and levels will allow for a deeper understanding of the complex interrelationship of the newborn's skin maturation. This trial is registered with ClinicalTrials.gov (Identifier: NCT04759924).
怀孕会导致多种皮肤变化，但关于皮肤结构和功能变化的证据稀少。对一岁以内儿童皮肤结构和功能的研究结果显示皮肤迅速成熟，但有证据表明，尤其是皮肤的持水和转运机制与成年人不同。重要的问题包括母体皮肤特性是否能预测婴儿的皮肤状况，如果可以，是如何预测的。这对于皮肤微生物群尤其重要，因为它与宿主密切相互作用，并被认为在许多皮肤疾病中起作用。因此，本研究的目的是探讨孕妇及其新生儿在孕期及产后头六个月的皮肤和头发特征及其关联。
本研究采用观察性纵向设计。我们通过在妇科医生候诊区和医院门诊服务处开展广告活动，招募18至45岁的怀孕女性。目标是最终样本量达到100名女性。我们进行无创、标准化的皮肤、头发和皮肤微生物群测量。我们在孕期建立基线访视，最晚在分娩前四周进行。我们为母亲及其新生儿安排产后四周和六个月的随访。我们将根据测量的尺度水平，使用频率和随时间的关联来计算描述性统计方法。以前大多数研究婴儿皮肤微生物群及其关联的研究采用横断面设计，并且关注小样本中的特定特征。在我们的纵向研究中，我们将描述母亲及其新生儿广泛的个体和环境特征，以评估与皮肤参数的相互关系及其随时间的变化。考虑这些多个变量和水平的组合将有助于更深入地理解新生儿皮肤成熟的复杂相互关系。本试验已在ClinicalTrials.gov注册（标识符：NCT04759924）。
