深海来源真菌 FS702 中的细胞毒性吡喃酮衍生物。

Cytotoxic pyrone derivatives from the deep-sea-derived fungus FS702.

机构信息

School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China.

State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, China.

出版信息

Nat Prod Res. 2024 Feb-Mar;38(4):594-600. doi: 10.1080/14786419.2023.2187794. Epub 2023 Mar 20.

DOI:10.1080/14786419.2023.2187794

PMID:36938638

Abstract

Two new compounds ()-6-((8)-hydroxypropyl)-2-methyl-5,6-dihydro-4-pyran-4-one () and ()-6-((8)-hydroxypropyl)-2-methyl-5,6-dihydro-4-pyran-4-one (), together with four known compounds were isolated from the marine-derived fungus FS702. The structures of these compounds were determined on the basis of extensive spectroscopic analysis including 1D/2D NMR, IR, UV, HRESIMS, ECD calculations as well as the modified Mosher's method. Cytotoxic assay results showed that compound had significant cytotoxic activity against SF-268, MCF-7, HepG-2, and A549 cells lines with IC values of 0.16, 0.47, 0.33 and 0.23 µM, respectively.

摘要

从海洋来源真菌 FS702 中分离得到了两个新化合物（）-6-((8)-羟基丙基)-2-甲基-5,6-二氢-4-吡喃-4-酮 () 和 ()-6-((8)-羟基丙基)-2-甲基-5,6-二氢-4-吡喃-4-酮 ()，以及四个已知化合物。这些化合物的结构是基于广泛的光谱分析确定的，包括 1D/2D NMR、IR、UV、HRESIMS、ECD 计算以及改进的 Mosher 方法。细胞毒性试验结果表明，化合物对 SF-268、MCF-7、HepG-2 和 A549 细胞系具有显著的细胞毒性活性，IC 值分别为 0.16、0.47、0.33 和 0.23 μM。