Sanderson C J, O'Garra A, Warren D J, Klaus G G
Proc Natl Acad Sci U S A. 1986 Jan;83(2):437-40. doi: 10.1073/pnas.83.2.437.
A mouse lymphokine that stimulates the production of functional eosinophils in liquid bone marrow cultures has recently been described [Sanderson, C.J., Warren, D.J. & Strath, M. (1985) J. Exp. Med. 162, 60-74]. This factor appears to be specific for the eosinophil lineage in hemopoietic differentiation and is analogous to colony-stimulating factors described for other hemopoietic lineages. In this paper we report that this factor appears to be identical to the B-cell growth factor II described by Swain and Dutton [Swain, S.L. & Dutton, R.W. (1982) J. Exp. Med. 156, 1821-1834]. This conclusion is based on the coordinate expression of the two activities by a panel of alloreactive T-cell clones and lines and on copurification through a series of protein separation techniques. The reason for a single lymphokine's having these widely differing biological activities is unclear, and its duality presents problems in using terminology based on either assay system. For this reason we propose the name "interleukin 4" for this molecule, and we suggest the defining property should be its eosinophil-differentiating activity.
最近有人描述了一种小鼠淋巴因子，它能刺激液体骨髓培养物中功能性嗜酸性粒细胞的产生[桑德森，C.J.，沃伦，D.J.和斯特拉斯，M.（1985年）《实验医学杂志》162卷，60 - 74页]。这种因子在造血分化过程中似乎对嗜酸性粒细胞谱系具有特异性，类似于针对其他造血谱系所描述的集落刺激因子。在本文中，我们报告这种因子似乎与斯温及达顿所描述的B细胞生长因子II相同[斯温，S.L.和达顿，R.W.（1982年）《实验医学杂志》156卷，1821 - 1834页]。这一结论基于一组同种异体反应性T细胞克隆和系对这两种活性的协同表达，以及通过一系列蛋白质分离技术的共同纯化。单一淋巴因子具有这些差异很大的生物学活性的原因尚不清楚，而且它的双重性在使用基于任何一种检测系统的术语时都带来了问题。因此，我们建议将该分子命名为“白细胞介素4”，并认为其决定性特性应为其嗜酸性粒细胞分化活性。
