Tang Haishuang, Wang Qingsong, Xu Fengfeng, Zhang Xiaoxi, Zeng Zhangwei, Yan Yazhou, Lu Zhiwen, Xue Gaici, Zuo Qiao, Luo Yin, Liu Jianmin, Huang Qinghai
Department of Neurosurgery, Changhai Hospital, Naval Military Medical University, 168 Changhai Road, Shanghai, 200433, People's Republic of China.
Naval Medical Center of PLA, Naval Military Medical University, Shanghai, 200050, People's Republic of China.
Chin Neurosurg J. 2021 Dec 1;7(1):44. doi: 10.1186/s41016-021-00260-2.
In modern society, subarachnoid hemorrhage, mostly caused by intracranial aneurysm rupture, is accompanied by high disability and mortality rate, which has become a major threat to human health. Till now, the etiology of intracranial aneurysm has not been entirely clarified. In recent years, more and more studies focus on the relationship between hemodynamics and intracranial aneurysm. Under the physiological condition, the mechanical force produced by the stable blood flow in the blood vessels keeps balance with the structure of the blood vessels. When the blood vessels are stimulated by the continuous abnormal blood flow, the functional structure of the blood vessels changes, which becomes the pathophysiological basis of the inflammation and atherosclerosis of the blood vessels and further promotes the occurrence and development of the intracranial aneurysm. This review will focus on the relationship between hemodynamics and intracranial aneurysms, will discuss the mechanism of occurrence and development of intracranial aneurysms, and will provide a new perspective for the research and treatment of intracranial aneurysms.
在现代社会，蛛网膜下腔出血大多由颅内动脉瘤破裂引起，其致残率和死亡率很高，已成为对人类健康的一大威胁。到目前为止，颅内动脉瘤的病因尚未完全阐明。近年来，越来越多的研究聚焦于血流动力学与颅内动脉瘤之间的关系。在生理条件下，血管中稳定血流产生的机械力与血管结构保持平衡。当血管受到持续异常血流的刺激时，血管的功能结构发生变化，这成为血管炎症和动脉粥样硬化的病理生理基础，并进一步促进颅内动脉瘤的发生和发展。本综述将聚焦于血流动力学与颅内动脉瘤之间的关系，探讨颅内动脉瘤的发生发展机制，并为颅内动脉瘤的研究和治疗提供新的视角。
