An Dong, Wu Xin, Gong Yaolin, Li Wenlu, Dai Guidong, Lu Xiaofei, Yu Liangmin, Ren Wen Xiu, Qiu Meng, Shu Jian
Frontiers Science Center for Deep Ocean Multispheres and Earth System, and Key Laboratory of Marine Chemistry Theory and Technology, Ministry of Education, Ocean University of China, Qingdao 266100, P. R. China.
Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, P. R. China.
Nanophotonics. 2022 Oct 10;11(22):5177-5188. doi: 10.1515/nanoph-2022-0533. eCollection 2022 Dec.
Two-dimensional transition metal carbides and nitrides (MXenes) nanosheets with high photothermal conversion efficiency as well as photothermal stability can efficiently generate remarkable hyperthermia for photothermal therapy (PTT) of cancer. However, mono-MXenes cannot exhibit precise diagnosis and treatment to complete ablation of cancer cells in the PTT process. To overcome this dilemma, an "all-in-one" nanoplatform of titanium carbide (TiC) MXene-based composite nanosheets is developed for magnetic resonance imaging (MRI)-guided multi-modal hyperthermia and chemodynamic tumor ablation, which was achieved by bonding of manganese ion on the surface of TiC, and then was the functionalized nanosheets was modified by biocompatible PEG (Mn-TiC@PEG). Due to magnetic and Fenton-like catalytic properties of Mn components, Mn-TiC@PEG not only acted as the contrast agents for T-weighted MRI (relaxivity value of 1.05 mM s), but also converted cellular HO into highly toxic hydroxyl radicals (·OH) mediated chemodynamic therapy (CDT). Moreover, Furthermore, Mn-TiC@PEG can efficiently suppressed tumor-growth by PTT, due to the high photothermal conversion capability and photothermal stability. As a proof-of-concept model, the as-designed Mn-TiC@PEG nanoplatform shows simultaneous MRI and dual-modal treatment for effective suppression of tumor with minimized side effects both and , indicating the great potential for clinical cancer theranostics.
具有高光热转换效率和光热稳定性的二维过渡金属碳化物和氮化物（MXenes）纳米片能够有效地产生显著的高温，用于癌症的光热疗法（PTT）。然而，单一的MXenes在PTT过程中无法实现精确诊断和治疗以完全消融癌细胞。为了克服这一困境，开发了一种基于碳化钛（TiC）MXene的复合纳米片的“一体化”纳米平台，用于磁共振成像（MRI）引导的多模态热疗和化学动力学肿瘤消融，这是通过在TiC表面键合锰离子实现的，然后用生物相容性聚乙二醇（Mn-TiC@PEG）对功能化纳米片进行修饰。由于锰组分的磁性和类芬顿催化特性，Mn-TiC@PEG不仅作为T加权MRI的造影剂（弛豫率值为1.05 mM s），还通过介导化学动力学疗法（CDT）将细胞内的H₂O₂转化为高毒性的羟基自由基（·OH）。此外，由于高光热转换能力和光热稳定性，Mn-TiC@PEG可以通过PTT有效地抑制肿瘤生长。作为概念验证模型，所设计的Mn-TiC@PEG纳米平台显示出同时进行MRI和双模态治疗，以有效抑制肿瘤且副作用最小，这表明其在临床癌症诊疗方面具有巨大潜力。
