Section on Pathophysiology and Molecular Pharmacology, Joslin Diabetes Center, Boston, MA, USA.
Department of Microbiology, Harvard Medical School, Boston, MA, USA.
Sci Rep. 2021 Dec 1;11(1):23230. doi: 10.1038/s41598-021-02431-8.
Managing postprandial glycemic response, or the increase in blood sugar following a meal, is a crucial component to maintaining healthy blood sugar in patients with diabetes. To test whether oral probiotics can impact postprandial glycemic response, E. coli Nissle 1917 (EcN) was evaluated in an oral glucose tolerance test. Oral gavage of EcN concurrent with a glucose bolus reduced the post-gavage glycemic response in mice. However, there was no difference in glycemic response when comparing EcN to a mutant deficient in glucose metabolism. This suggests that while EcN can alter glycemic response to a glucose bolus, this effect is not mediated by direct uptake of glucose. Of the possible indirect effects EcN could have, gastric emptying rate was highlighted as a likely cause, but EcN had no effect on gastric emptying rate in mice. This leaves many more possible indirect explanations for the interaction between EcN and host glucose metabolism to be explored in future work.
管理餐后血糖反应，即餐后血糖升高，是糖尿病患者维持健康血糖的关键组成部分。为了测试口服益生菌是否会影响餐后血糖反应，在口服葡萄糖耐量试验中评估了大肠杆菌 Nissle 1917（EcN）。与葡萄糖冲击同时口服 EcN 可降低小鼠的餐后血糖反应。然而，在比较 EcN 与葡萄糖代谢缺陷的突变体时，血糖反应没有差异。这表明，尽管 EcN 可以改变葡萄糖冲击后的血糖反应，但这种作用不是通过直接摄取葡萄糖介导的。在 EcN 可能具有的各种间接作用中，胃排空率被突出为可能的原因，但 EcN 对小鼠的胃排空率没有影响。这为 EcN 与宿主葡萄糖代谢之间的相互作用留下了更多可能的间接解释，有待在未来的工作中进一步探讨。
