Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran.
Invasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.
Mycopathologia. 2022 Feb;187(1):121-127. doi: 10.1007/s11046-021-00605-6. Epub 2021 Dec 2.
Candida auris, a multidrug-resistant nosocomial pathogen, has emerged globally with high morbidity and mortality among immunocompromised individuals and COVID19 hospitalized patients. Five major clades of C. auris have been previously described. The fifth clade is exclusively found in Iran where C. auris isolates are genetically distinct from other clades by > 200,000 single-nucleotide polymorphisms. The origin of C. auris remains unclear, and limited clinical data are available at present regarding clade V infection or colonization. Herein, another case of otomycosis in Iran caused by an isolate of C. auris belonging to the fifth clade is reported. Genotyping revealed that the obtained C. auris isolate from Isfahan clustered with earlier clade V isolates from Babol, cities around 600 km separated, which indicates that C. auris clade V is established in Iran. C. auris is thought to exist more commonly in Iran, given that limited diagnostic capacity in the country has probably curbed the identification of more C. auris cases. Therefore, surveillance of the environment, patients and healthcare facilities in different geographical regions in Iran is urgently required.
耳念珠菌是一种具有多重耐药性的医院获得性病原体，在免疫功能低下者和 COVID19 住院患者中具有较高的发病率和死亡率，已在全球范围内出现。此前已描述了耳念珠菌的 5 个主要谱系。第五个谱系仅在伊朗发现，与其他谱系相比，伊朗的耳念珠菌分离株在基因上存在超过 20 万个单核苷酸多态性。耳念珠菌的起源仍不清楚，目前关于谱系 V 感染或定植的临床数据有限。本文报告了伊朗另一个由第五个谱系的耳念珠菌引起的耳真菌病病例。基因分型显示，从伊斯法罕获得的耳念珠菌分离株与来自相距 600 公里的巴博尔市的早期谱系 V 分离株聚类，这表明耳念珠菌谱系 V 在伊朗已经建立。由于该国的诊断能力有限，可能限制了更多耳念珠菌病例的鉴定，因此，据认为耳念珠菌在伊朗更为常见。因此，迫切需要在伊朗不同地理区域监测环境、患者和医疗机构。
