Ocean State Veterinary Specialists, East Greenwich, Rhode Island, USA.
Can Vet J. 2021 Dec;62(12):1298-1303.
A 5-month-old puppy was evaluated for rapidly progressive neurologic signs and pyrexia. Magnetic resonance imaging showed multifocal meningoencephalitis with transtentorial and foramen magnum herniation. A cerebrospinal fluid tap revealed highly cellular fluid, and the puppy was euthanized. Histopathology showed lymphoplasmacytic and neutrophilic meningoencephalitis. Viral polymerase chain reaction testing for Eastern equine encephalitis was positive. Rapid progression of neurologic signs and respiratory arrest necessitated mechanical ventilation. Severe hypernatremia, most consistent with central diabetes insipidus, developed. Key clinical message: Transtentorial and foramen magnum herniation and high cerebrospinal fluid cell counts may be indicators of poor prognosis. Brain death, respiratory arrest, and central diabetes insipidus may also ensue with Eastern equine encephalitis infection.
一只 5 个月大的小狗因进行性神经症状和发热接受评估。磁共振成像显示多灶性脑膜脑炎伴小脑幕切迹疝和枕骨大孔疝。腰椎穿刺显示脑脊液高度细胞化，小狗被安乐死。组织病理学显示淋巴浆细胞性和嗜中性粒细胞性脑膜脑炎。东方马脑炎病毒聚合酶链反应检测呈阳性。神经症状迅速进展和呼吸停止需要机械通气。严重的高钠血症发展，最符合中枢性尿崩症。主要临床信息：小脑幕切迹疝和枕骨大孔疝以及高脑脊液细胞计数可能是预后不良的指标。东方马脑炎感染也可能导致脑死亡、呼吸停止和中枢性尿崩症。
