Fraser Barbara, Peters Alexandra E, Sutherland Jessie M, Liang Mingtao, Rebourcet Diane, Nixon Brett, Aitken Robert J
Priority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.
Pregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Front Physiol. 2021 Nov 11;12:753686. doi: 10.3389/fphys.2021.753686. eCollection 2021.
A growing body of research has confirmed that nanoparticle (NP) systems can enhance delivery of therapeutic and imaging agents as well as prevent potentially damaging systemic exposure to these agents by modifying the kinetics of their release. With a wide choice of NP materials possessing different properties and surface modification options with unique targeting agents, bespoke nanosystems have been developed for applications varying from cancer therapeutics and genetic modification to cell imaging. Although there remain many challenges for the clinical application of nanoparticles, including toxicity within the reproductive system, some of these may be overcome with the recent development of biodegradable nanoparticles that offer increased biocompatibility. In recognition of this potential, this review seeks to present recent NP research with a focus on the exciting possibilities posed by the application of biocompatible nanomaterials within the fields of male reproductive medicine, health, and research.
越来越多的研究证实，纳米颗粒（NP）系统可以增强治疗剂和成像剂的递送，并通过改变其释放动力学来防止这些药剂对全身造成潜在的损害性暴露。由于有多种具有不同特性的NP材料可供选择，以及可与独特靶向剂进行表面修饰的选项，因此已经开发出定制的纳米系统，用于从癌症治疗、基因修饰到细胞成像等各种应用。尽管纳米颗粒的临床应用仍然面临许多挑战，包括生殖系统内的毒性，但随着最近可生物降解纳米颗粒的发展，其生物相容性有所提高，其中一些挑战可能会被克服。认识到这种潜力，本综述旨在介绍最近的NP研究，重点关注生物相容性纳米材料在男性生殖医学、健康和研究领域应用所带来的令人兴奋的可能性。
