Diao Hui, Yan Jiayou, Li Shuwei, Kuang Shengyao, Wei Xiaolan, Zhou Mengjia, Zhang Jinxiu, Huang Chongbo, He Peng, Tang Wenjie
Animal Breeding and Genetics Key Laboratory of Sichuan Province, Sichuan Academy of Animal Science, Chengdu, China.
Sichuan Animtech Biology Development Co., Ltd, Chengdu, China.
Front Microbiol. 2021 Oct 28;12:771617. doi: 10.3389/fmicb.2021.771617. eCollection 2021.
The present study aimed to investigate the effects of dietary zinc sources on the growth performance and gut health of weaned piglets. In total, 96 Duroc × Landrace × Yorkshire (DLY) weaned piglets with an initial average body weight of 8.81±0.42kg were divided into four groups, with six replicates per treatment and four pigs per replicate. The dietary treatment groups were as follows: (1) control group, basal diet; (2) zinc sulphate (ZnSO4) group, basal diet +100mg/kg ZnSO4; (3) glycine zinc (Gly-Zn) group, basal diet +100mg/kg Gly-Zn and (4) zinc lactate group, and basal diet +100mg/kg zinc lactate. The whole trial lasted for 28days. Decreased F/G was noted in the Gly-Zn and zinc lactate groups (<0.05). The zinc lactate group had a lower diarrhea rate than the control group (<0.05). Moreover, the ZnSO4, Gly-Zn, and zinc lactate groups had significantly higher apparent total tract digestibility of dry matter (DM), crude protein (CP), ether extract (EE), crude ash, and zinc than the control group (<0.05). The Gly-Zn and zinc lactate groups had higher jejunal villus height and a higher villus height:crypt depth ratio than the control group (<0.05). In addition, the ZnSO4, Gly-Zn and zinc lactate groups had a significantly lower mRNA expression level of jejunal ZRT/IRT-like protein 4 (ZIP4) and higher mRNA expression level of jejunal interleukin-1β (IL-1β) than the control group (<0.05). The mRNA expression level of jejunal zinc transporter 2 (ZNT2) was higher and that of jejunal Bcl-2-associated X protein (Bax) was lower in the Gly-Zn and zinc lactate groups than in the control group (<0.05). Moreover, the zinc lactate group had a higher count of spp. in the cecal digesta and higher mRNA expression levels of jejunal occludin and mucin 2 (MUC2) than the control group (<0.05). In conclusion, dietary supplementation with 100mg/kg ZnSO4, Gly-Zn, or zinc lactate could improve the growth performance and gut barrier function of weaned piglets. Dietary supplementation with organic zinc, particularly zinc lactate, had the best effect.
本研究旨在探讨日粮锌源对断奶仔猪生长性能和肠道健康的影响。总共96头初始平均体重为8.81±0.42kg的杜洛克×长白×大白（DLY）断奶仔猪被分为四组，每组处理设6个重复，每个重复4头猪。日粮处理组如下：（1）对照组，基础日粮；（2）硫酸锌（ZnSO4）组，基础日粮+100mg/kg ZnSO4；（3）甘氨酸锌（Gly-Zn）组，基础日粮+100mg/kg Gly-Zn；（4）乳酸锌组，基础日粮+100mg/kg乳酸锌。整个试验持续28天。甘氨酸锌组和乳酸锌组的料重比降低（<0.05）。乳酸锌组的腹泻率低于对照组（<0.05）。此外，硫酸锌组、甘氨酸锌组和乳酸锌组干物质（DM）、粗蛋白（CP）、乙醚提取物（EE）、粗灰分和锌的表观全肠道消化率显著高于对照组（<0.05）。甘氨酸锌组和乳酸锌组空肠绒毛高度及绒毛高度与隐窝深度比值高于对照组（<0.05）。另外，硫酸锌组、甘氨酸锌组和乳酸锌组空肠ZRT/IRT样蛋白4（ZIP4）的mRNA表达水平显著低于对照组，空肠白细胞介素-1β（IL-1β）的mRNA表达水平高于对照组（<0.05）。甘氨酸锌组和乳酸锌组空肠锌转运体2（ZNT2）的mRNA表达水平高于对照组，空肠Bcl-2相关X蛋白（Bax）的mRNA表达水平低于对照组（<0.05）。此外，乳酸锌组盲肠内容物中 spp.的数量以及空肠闭合蛋白和黏蛋白2（MUC2）的mRNA表达水平高于对照组（<0.05）。总之，日粮中添加100mg/kg ZnSO4、Gly-Zn或乳酸锌可提高断奶仔猪的生长性能和肠道屏障功能。日粮中添加有机锌，尤其是乳酸锌，效果最佳。
