Deep level set method for optic disc and cup segmentation on fundus images.

Glaucoma is a leading cause of blindness. The measurement of vertical cup-to-disc ratio combined with other clinical features is one of the methods used to screen glaucoma. In this paper, we propose a deep level set method to implement the segmentation of optic cup (OC) and optic disc (OD). We present a multi-scale convolutional neural network as the prediction network to generate level set initial contour and evolution parameters. The initial contour will be further refined based on the evolution parameters. The network is integrated with augmented prior knowledge and supervised by active contour loss, which makes the level set evolution yield more accurate shape and boundary details. The experimental results on the REFUGE dataset show that the IoU of the OC and OD are 93.61% and 96.69%, respectively. To evaluate the robustness of the proposed method, we further test the model on the Drishthi-GS1 dataset. The segmentation results show that the proposed method outperforms the state-of-the-art methods.