Zhejiang Provincial Key Lab of Geriatrics and Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou, China.
School of Stomatology, Hangzhou Normal University, Hangzhou, China.
Front Public Health. 2021 Nov 11;9:761069. doi: 10.3389/fpubh.2021.761069. eCollection 2021.
Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs), the effect of EMFs on aging has also attracted attention. Cells are the basic unit of organs and body tissues, and cellular senescence plays an important role in the aging process. The effect of EMFs on cellular senescence has been investigated in a few studies, but the information is limited, and the results are inconsistent; thus, further investigation is required. In this study, we investigated the effect of 10 Hz pulsed magnetic fields (MFs) on cellular senescence in a 2BS cell line, isolated from human fetal lung fibroblasts, and found that intermittent (1 d on/1 d off) exposure to 10 Hz pulsed MFs at 1.0 mT for 2 weeks induced DNA damage, but no other significant phenotype of cellular senescence in 2BS cells.
人口老龄化的迅速发展导致了全球老年疾病负担。作为多种与年龄相关疾病的最大危险因素，衰老不仅是基因型的结果，而且与外部因素密切相关。随着电磁场（EMF）的使用迅速扩大，EMF 对衰老的影响也引起了关注。细胞是器官和身体组织的基本单位，细胞衰老在衰老过程中起着重要作用。已有一些研究探讨了 EMF 对细胞衰老的影响，但信息有限，结果不一致；因此，需要进一步研究。在这项研究中，我们研究了 10 Hz 脉冲磁场（MFs）对来源于人胎儿肺成纤维细胞的 2BS 细胞系细胞衰老的影响，结果发现，间歇性（1 天照射/1 天休息）暴露于 10 Hz 脉冲 MFs（1.0 mT）2 周会引起 DNA 损伤，但在 2BS 细胞中没有引起其他明显的细胞衰老表型。
