高压氧治疗长新冠：一种极具前景干预措施的早期评估。
Hyperbaric oxygen therapy for the treatment of long COVID: early evaluation of a highly promising intervention.
机构信息
University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK, Warwick Medical School, Coventry, UK and Coventry University, Coventry, UK
Midlands Diving Chamber, Rugby, UK.
出版信息
Clin Med (Lond). 2021 Nov;21(6):e629-e632. doi: 10.7861/clinmed.2021-0462.
BACKGROUND
Long COVID is a common occurrence following COVID-19 infection. The most common symptom reported is fatigue. Limited interventional treatment options exist. We report the first evaluation of hyperbaric oxygen therapy (HBOT) for long COVID treatment.
METHODS
A total of 10 consecutive patients received 10 sessions of HBOT to 2.4 atmospheres over 12 days. Each treatment session lasted 105 minutes, consisting of three 30-minute exposures to 100% oxygen, interspersed with 5-minute air breaks. Validated fatigue and cognitive scoring assessments were performed at day 1 and 10. Statistical analysis was with Wilcoxon signed-rank testing reported alongside effect sizes.
RESULTS
HBOT yielded a statistically significant improvement in the Chalder fatigue scale (p=0.0059; d=1.75 (very large)), global cognition (p=0.0137; d=-1.07 (large)), executive function (p=0.0039; d=-1.06 (large)), attention (p=0.0020; d=-1.2 (very large)), information processing (p=0.0059; d=-1.25 (very large)) and verbal function (p=0.0098; d=-0.92 (large)).
CONCLUSION
Long COVID-related fatigue can be debilitating, and may affect young people who were previously in economic employment. The results presented here suggest potential benefits of HBOT, with statistically significant results following 10 sessions.
背景
长新冠是新冠感染后的常见现象。报告最多的常见症状是疲劳。目前干预治疗的选择有限。我们首次报告高压氧治疗（HBOT）治疗长新冠的情况。
方法
共有 10 名连续患者接受了 10 次 HBOT 治疗，压力为 2.4 大气压，共 12 天。每次治疗持续 105 分钟，包括三次 30 分钟的 100%氧气暴露，中间间隔 5 分钟的空气休息。在第 1 天和第 10 天进行了有效的疲劳和认知评分评估。统计分析采用 Wilcoxon 符号秩检验，并报告了效应量。
结果
HBOT 使 Chalder 疲劳量表（p=0.0059；d=1.75（非常大））、整体认知（p=0.0137；d=-1.07（大））、执行功能（p=0.0039；d=-1.06（大））、注意力（p=0.0020；d=-1.2（非常大））、信息处理（p=0.0059；d=-1.25（非常大））和语言功能（p=0.0098；d=-0.92（大））均有统计学显著改善。
结论
长新冠相关疲劳可能使人衰弱，并且可能影响以前处于经济就业中的年轻人。这里提出的结果表明 HBOT 具有潜在益处，10 次治疗后有统计学显著效果。
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