Faculty of Bio-Sciences, Institute of Bio-Sciences and Technology, Shri Ramswaroop Memorial University, Lucknow- Deva Road, Barabanki, 225003, Uttar Pradesh, India.
Department of Biotechnology, National Institute of Technology, Raipur, Chhattisgarh, India.
Clin J Gastroenterol. 2022 Feb;15(1):1-10. doi: 10.1007/s12328-021-01555-8. Epub 2021 Dec 4.
Irritable bowel syndrome (IBS) is a multifactorial disease of which infection, as well as inflammation, has recently been considered as an important cause. Inflammation works as a potential pathway for the pathogenesis of IBS. In this review, we have discussed the targeted therapy of IBS. We used the search term "inflammation in IBS" and "proinflammatory" and "antiinflammatory cytokines and IBS" using PubMed, MEDLINE, and Google Scholar. The literature search included only articles written in the English language. We have also reviewed currently available anti-inflammatory treatment and future perspectives. Cytokine imbalance in the systematic circulation and the intestinal mucosa may also characterize IBS presentation. Imbalances of pro-and anti-inflammatory cytokines and polymorphisms in cytokine genes have been reported in IBS. The story of targeted therapy of IBS with anti-inflammatory cytokines is far from complete and it seems that it has only just begun. This review describes the key issues related to pro-inflammatory cytokines associated with IBS, molecular regulation of immune response in IBS, inhibitors of pro-inflammatory cytokines in IBS, and clinical perspectives of pro- and anti-inflammatory cytokines in IBS.
肠易激综合征（IBS）是一种多因素疾病，最近感染和炎症也被认为是重要的病因。炎症作为 IBS 发病机制的一个潜在途径。在这篇综述中，我们讨论了 IBS 的靶向治疗。我们使用了搜索词“IBS 中的炎症”和“促炎”以及“抗炎细胞因子和 IBS”，并使用了 PubMed、MEDLINE 和 Google Scholar。文献检索仅包括用英文撰写的文章。我们还回顾了目前可用的抗炎治疗方法和未来的展望。系统性循环和肠黏膜中的细胞因子失衡也可能是 IBS 表现的特征。IBS 中促炎和抗炎细胞因子的失衡以及细胞因子基因的多态性已被报道。用抗炎细胞因子靶向治疗 IBS 的故事远未完成，似乎才刚刚开始。这篇综述描述了与 IBS 相关的促炎细胞因子、IBS 中免疫反应的分子调节、IBS 中促炎细胞因子抑制剂以及 IBS 中促炎和抗炎细胞因子的临床观点等关键问题。
