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三氯乙烯对人体前庭眼动系统的影响。

Effects of trichloroethylene on the human vestibulo-oculomotor system.

作者信息

Larsby B, Tham R, Eriksson B, Hydén D, Odkvist L, Liedgren C, Bunnfors I

出版信息

Acta Otolaryngol. 1986 Mar-Apr;101(3-4):193-9. doi: 10.3109/00016488609132827.

DOI:10.3109/00016488609132827
PMID:3486543
Abstract

Ten healthy volunteers were subjected to a vestibulo-oculomotor test battery before, during and 1 hour after trichloroethylene exposure. The concentration of trichloroethylene in inspiratory air was 32-78 ppm (176-429 mg/m3). The concentration of trichloroethylene in venous blood was followed throughout the experiment. The mean pulmonary uptake was estimated. Each test person was also subjected to a control experiment, breathing air free of trichloroethylene. A decreased ability to visually suppress the vestibulo-oculomotor reflex during sinusoidal stimulation was noticed during trichloroethylene exposure. One hour after exposure the test subjects showed a decreased maximum velocity of the voluntary saccade and a decreased ability to follow a sinusoidally moving target.

摘要

10名健康志愿者在三氯乙烯暴露前、暴露期间和暴露后1小时接受了一系列前庭眼动测试。吸入空气中三氯乙烯的浓度为32 - 78 ppm(176 - 429毫克/立方米)。在整个实验过程中监测静脉血中三氯乙烯的浓度。估算了平均肺摄取量。每位受试者还进行了对照实验,即呼吸不含三氯乙烯的空气。在三氯乙烯暴露期间,观察到在正弦刺激过程中视觉抑制前庭眼动反射的能力下降。暴露后1小时,受试者的随意扫视最大速度降低,跟踪正弦运动目标的能力下降。

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