Takashima S, Mito T, Ando Y
Brain Dev. 1986;8(1):25-30. doi: 10.1016/s0387-7604(86)80116-4.
Periventricular white matter hemorrhage (PWMH) was frequently found in very low-birth weight infants with perinatal asphyxia or respiratory distress. Primary PWMH with or without intraventricular rupture was found at the deep arterial borderzones of the frontal or occipital lobes. The ischemic tissue damage induced by hypoperfusion may be a predisposing factor for PWMH. However, the high incidence of visceral intravascular thrombi and the fan-shaped appearance of hemorrhage suggested venous hemorrhagic infarction. Venous thrombosis with coagulopathy may be an important factor for the pathogenesis of PWMH.
脑室周围白质出血（PWMH）常见于患有围产期窒息或呼吸窘迫的极低出生体重儿。在额叶或枕叶的深部动脉边缘区发现有或无脑室破裂的原发性PWMH。低灌注引起的缺血性组织损伤可能是PWMH的一个诱发因素。然而，内脏血管内血栓的高发生率和出血的扇形外观提示为静脉出血性梗死。伴有凝血病的静脉血栓形成可能是PWMH发病机制的一个重要因素。
