Division of Sleep and Circadian Disorders and Division of Sleep Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Nuffield Department of Medicine, University of Oxford, Oxford, UK.
J Biol Rhythms. 2022 Feb;37(1):124-129. doi: 10.1177/07487304211059315. Epub 2021 Dec 4.
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a global crisis with unprecedented challenges for public health. Vaccinations against SARS-CoV-2 have slowed the incidence of new infections and reduced disease severity. As the time of day of vaccination has been reported to influence host immune responses to multiple pathogens, we quantified the influence of SARS-CoV-2 vaccination time, vaccine type, participant age, sex, and days post-vaccination on anti-Spike antibody responses in health care workers. The magnitude of the anti-Spike antibody response is associated with the time of day of vaccination, vaccine type, participant age, sex, and days post-vaccination. These results may be relevant for optimising SARS-CoV-2 vaccine efficacy.
由严重急性呼吸系统综合症冠状病毒 2 型（SARS-CoV-2）引起的 COVID-19 大流行是一场全球危机，对公共卫生带来了前所未有的挑战。针对 SARS-CoV-2 的疫苗接种减缓了新感染的发生并降低了疾病的严重程度。由于接种疫苗的时间已被报道会影响宿主对多种病原体的免疫反应，我们量化了 SARS-CoV-2 接种时间、疫苗类型、参与者年龄、性别和接种后天数对医护人员的抗刺突抗体反应的影响。抗刺突抗体反应的强度与接种时间、疫苗类型、参与者年龄、性别和接种后天数有关。这些结果可能与优化 SARS-CoV-2 疫苗的功效有关。
