Brouwers Tamara M J, Çobanoğlu Ümmü Gülsüm, Geers Daryl, Rietdijk Wim J R, Gommers Lennert, Bogers Susanne, Lammers Gert Jan, van der Horst Gijsbertus T J, Chaves Inês, GeurtsvanKessel Corine H, Koch Birgit C P, de Vries Rory D, van Baarle Debbie, van der Kuy Hugo M, Lammers-van der Holst Heidi M
Center for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, Groningen, The Netherlands.
J Sleep Res. 2025 Aug;34(4):e14431. doi: 10.1111/jsr.14431. Epub 2024 Dec 10.
Shift work can cause circadian misalignment, which often results in sleeping problems and has been associated with immune dysfunction. To better understand the impact of shift work on a primary immune response to vaccination, we compared severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific humoral and cellular immune responses after one injection of the messenger RNA (mRNA)-1273 vaccine between day workers (n = 24) and night shift workers (n = 21). In addition, duration and quality of sleep were assessed for a period of 7 days around the time of vaccination using actigraphy and daily sleep diaries, and their relationship with immunogenicity of mRNA-1273 vaccination was studied. We found that median total sleep time on the 2 days immediately after vaccination, which coincided with the days that night shift workers worked night shifts, was significantly lower in night shift workers (342 and 318 min) than day workers (431 and 415 min) (both p < 0.001). There was no difference in sleep quality between day workers and night shift workers. Furthermore, no difference in the antibody response between the two groups was observed, yet night shift workers had a significantly higher virus-specific T-cell response than day workers 28 days after immunisation (p = 0.013). Multivariate regression analysis showed no association between sleep duration, sleep quality and SARS-CoV-2-specific humoral or cellular immune responses. Collectively, these findings indicate that shift work-induced sleep loss and night shift work have little to no effect on the primary immune response to mRNA-based COVID-19 vaccination.
轮班工作会导致昼夜节律失调，这通常会引发睡眠问题，并与免疫功能紊乱有关。为了更好地了解轮班工作对疫苗接种后主要免疫反应的影响，我们比较了白班工作者（n = 24）和夜班工作者（n = 21）在接种一针信使核糖核酸（mRNA）-1273疫苗后针对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的体液免疫和细胞免疫反应。此外，在接种疫苗前后7天的时间里，使用活动记录仪和每日睡眠日记评估睡眠时长和质量，并研究它们与mRNA-1273疫苗免疫原性的关系。我们发现，接种疫苗后紧接着的2天（这两天恰逢夜班工作者上夜班），夜班工作者的总睡眠时间中位数（342和318分钟）显著低于白班工作者（431和415分钟）（p均<0.001）。白班工作者和夜班工作者的睡眠质量没有差异。此外，两组之间的抗体反应没有差异，但在免疫接种28天后，夜班工作者的病毒特异性T细胞反应显著高于白班工作者（p = 0.013）。多变量回归分析表明，睡眠时长、睡眠质量与SARS-CoV-2特异性体液免疫或细胞免疫反应之间没有关联。总体而言，这些发现表明，轮班工作导致的睡眠不足和夜班工作对基于mRNA的COVID-19疫苗接种后的主要免疫反应几乎没有影响。
