Das Saurav, Das Debapratim
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, India.
Front Chem. 2021 Nov 16;9:770102. doi: 10.3389/fchem.2021.770102. eCollection 2021.
Peptide-based hydrogels have captivated remarkable attention in recent times and serve as an excellent platform for biomedical applications owing to the impressive amalgamation of unique properties such as biocompatibility, biodegradability, easily tunable hydrophilicity/hydrophobicity, modular incorporation of stimuli sensitivity and other functionalities, adjustable mechanical stiffness/rigidity and close mimicry to biological molecules. Putting all these on the same plate offers smart soft materials that can be used for tissue engineering, drug delivery, 3D bioprinting, wound healing to name a few. A plethora of work has been accomplished and a significant progress has been realized using these peptide-based platforms. However, designing hydrogelators with the desired functionalities and their self-assembled nanostructures is still highly serendipitous in nature and thus a roadmap providing guidelines toward designing and preparing these soft-materials and applying them for a desired goal is a pressing need of the hour. This review aims to provide a concise outline for that purpose and the design principles of peptide-based hydrogels along with their potential for biomedical applications are discussed with the help of selected recent reports.
近年来，基于肽的水凝胶备受关注，由于其具有生物相容性、生物可降解性、易于调节的亲水性/疏水性、模块化引入刺激敏感性和其他功能、可调节的机械刚度/硬度以及与生物分子的紧密模拟等独特性质的出色融合，它成为生物医学应用的理想平台。将所有这些特性集于一身，可提供智能软材料，可用于组织工程、药物递送、3D生物打印、伤口愈合等诸多领域。使用这些基于肽的平台已经完成了大量工作并取得了重大进展。然而，设计具有所需功能的水凝胶剂及其自组装纳米结构本质上仍然具有很大的偶然性，因此，提供设计和制备这些软材料并将其应用于预期目标的指导方针的路线图是当务之急。本综述旨在为此提供一个简要概述，并借助近期选定的报告讨论基于肽的水凝胶的设计原则及其在生物医学应用中的潜力。
