Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Hematology, Oncology and Rheumatology, Heidelberg University Hospital, 69121 Heidelberg, Germany.
Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Trends Cancer. 2022 Mar;8(3):164-173. doi: 10.1016/j.trecan.2021.11.004. Epub 2021 Dec 3.
The complex determinants of health and disease can be determined when approached as a system of interactions of biological agents at different scales. Similar to the physicochemical properties that govern nucleic acids and proteins, there should be a finite set of rules that dictate the behavior of cells to form tissues. Thus, the occurrence of disease can be seen as flaws in processes that are governed by rules pertaining to multicellular structures. Multiplexed imaging is a technology that connects information that bridges multiple biological scales (i.e., molecules, cells, and tissues) and enables elucidation of rules associated with the formation of multicellular structures. Uncovering important multicellular structures associated with disease will propel a wave of development of new categories of diagnostics and therapeutics.
当将健康和疾病的复杂决定因素视为不同尺度的生物因素相互作用的系统时，可以确定这些因素。类似于控制核酸和蛋白质的物理化学性质，应该有一组有限的规则来支配细胞形成组织的行为。因此，可以将疾病的发生视为受与多细胞结构相关规则支配的过程中的缺陷。多重成像技术是一种连接跨越多个生物学尺度（即分子、细胞和组织）的信息的技术，并能够阐明与多细胞结构形成相关的规则。揭示与疾病相关的重要多细胞结构将推动新类别的诊断和治疗方法的发展浪潮。
