我们从中得到了哪些启示？
What have we learned?
机构信息
eLife, Cambridge, United Kingdom.
出版信息
Elife. 2021 Dec 7;10:e75830. doi: 10.7554/eLife.75830.
Abstract
As the final outputs of the Reproducibility Project: Cancer Biology are published, it is clear that preclinical research in cancer biology is not as reproducible as it should be.
摘要
随着《癌症生物学可重复性研究》的最终成果发布，很明显，癌症生物学的临床前研究并没有达到应有的可重复性。
相似文献
1
What have we learned?我们从中得到了哪些启示？
Elife. 2021 Dec 7;10:e75830. doi: 10.7554/eLife.75830.
2
Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology.《可重复性计划：癌症生物学》中未完成的已注册报告的实验。
Elife. 2021 Dec 7;10:e73430. doi: 10.7554/eLife.73430.
3
The Brazilian Reproducibility Initiative.巴西可重复性倡议。
Elife. 2019 Feb 5;8:e41602. doi: 10.7554/eLife.41602.
4
An open investigation of the reproducibility of cancer biology research.一项关于癌症生物学研究可重复性的公开调查。
Elife. 2014 Dec 10;3:e04333. doi: 10.7554/eLife.04333.
5
Is preclinical research in cancer biology reproducible enough?癌症生物学的临床前研究是否具有足够的可重复性？
Elife. 2021 Dec 7;10:e67527. doi: 10.7554/eLife.67527.
6
Investigating the replicability of preclinical cancer biology.探究癌症生物学的临床前可重复性。
Elife. 2021 Dec 7;10:e71601. doi: 10.7554/eLife.71601.
7
Challenges for assessing replicability in preclinical cancer biology.评估临床前癌症生物学可重复性面临的挑战。
Elife. 2021 Dec 7;10:e67995. doi: 10.7554/eLife.67995.
8
Can cancer researchers accurately judge whether preclinical reports will reproduce?癌症研究人员能否准确判断临床前报告是否会得到重现？
PLoS Biol. 2017 Jun 29;15(6):e2002212. doi: 10.1371/journal.pbio.2002212. eCollection 2017 Jun.
9
Accounting for reciprocal host-microbiome interactions in experimental science.在实验科学中考虑宿主-微生物组的相互作用。
Nature. 2016 Jun 9;534(7606):191-9. doi: 10.1038/nature18285.
10
How Modeling Standards, Software, and Initiatives Support Reproducibility in Systems Biology and Systems Medicine.建模标准、软件和计划如何支持系统生物学与系统医学中的可重复性。
IEEE Trans Biomed Eng. 2016 Oct;63(10):1999-2006. doi: 10.1109/TBME.2016.2555481. Epub 2016 Jun 2.
引用本文的文献
1
A metric of knowledge as information compression reflects reproducibility predictions for biomedical experiments.作为信息压缩的知识度量反映了生物医学实验的可重复性预测。
R Soc Open Sci. 2025 Jul 9;12(7):241446. doi: 10.1098/rsos.241446. eCollection 2025 Jul.
2
"Lost in translation?" Animal research in the era of precision medicine.“迷失在翻译中？”精准医学时代的动物研究。
J Transl Med. 2025 Feb 4;23(1):152. doi: 10.1186/s12967-025-06084-3.
3
Memory effects of prior subculture may impact the quality of multiomic perturbation profiles.先前亚培养可能会对多组学扰动谱的质量产生记忆效应。
Proc Natl Acad Sci U S A. 2024 Jul 16;121(29):e2313851121. doi: 10.1073/pnas.2313851121. Epub 2024 Jul 8.
4
Back to the Future of Neuropsychopharmacology.神经精神药理学的未来回溯
Adv Neurobiol. 2023;30:207-224. doi: 10.1007/978-3-031-21054-9_9.
5
Identifying barriers and enablers to rigorous conduct and reporting of preclinical laboratory studies.确定临床前实验室研究严谨实施和报告的障碍和促进因素。
PLoS Biol. 2023 Jan 5;21(1):e3001932. doi: 10.1371/journal.pbio.3001932. eCollection 2023 Jan.
6
Sharing resources to advance translational research.资源共享，推进转化研究。
Dis Model Mech. 2022 Oct 1;15(10). doi: 10.1242/dmm.049944. Epub 2022 Oct 31.
7
Assessing reproducibility of the core findings in cancer research.评估癌症研究中核心发现的可重复性。
iScience. 2022 Sep 13;25(10):105125. doi: 10.1016/j.isci.2022.105125. eCollection 2022 Oct 21.
8
Standards in semen examination: publishing reproducible and reliable data based on high-quality methodology.精液检查标准：基于高质量方法学发表可重复和可靠的数据。
Hum Reprod. 2022 Oct 31;37(11):2497-2502. doi: 10.1093/humrep/deac189.
9
Data Incompleteness May form a Hard-to-Overcome Barrier to Decoding Life's Mechanism.数据不完整性可能构成解码生命机制难以逾越的障碍。
Biology (Basel). 2022 Aug 12;11(8):1208. doi: 10.3390/biology11081208.
本文引用的文献
1
Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology.《可重复性计划：癌症生物学》中未完成的已注册报告的实验。
Elife. 2021 Dec 7;10:e73430. doi: 10.7554/eLife.73430.
2
Challenges for assessing replicability in preclinical cancer biology.评估临床前癌症生物学可重复性面临的挑战。
Elife. 2021 Dec 7;10:e67995. doi: 10.7554/eLife.67995.
3
Is preclinical research in cancer biology reproducible enough?癌症生物学的临床前研究是否具有足够的可重复性？
Elife. 2021 Dec 7;10:e67527. doi: 10.7554/eLife.67527.
4
Investigating the replicability of preclinical cancer biology.探究癌症生物学的临床前可重复性。
Elife. 2021 Dec 7;10:e71601. doi: 10.7554/eLife.71601.
5
Reproducibility: expect less of the scientific paper.可重复性：对科学论文的期望要降低。
Nature. 2021 Sep;597(7876):329-331. doi: 10.1038/d41586-021-02486-7.
6
The Brazilian Reproducibility Initiative.巴西可重复性倡议。
Elife. 2019 Feb 5;8:e41602. doi: 10.7554/eLife.41602.
7
A Survey on Data Reproducibility and the Effect of Publication Process on the Ethical Reporting of Laboratory Research.关于数据可重复性的调查，以及发表过程对实验室研究伦理报告的影响。
Clin Cancer Res. 2018 Jul 15;24(14):3447-3455. doi: 10.1158/1078-0432.CCR-18-0227. Epub 2018 Apr 11.
8
1,500 scientists lift the lid on reproducibility.1500名科学家揭开了可重复性的盖子。
Nature. 2016 May 26;533(7604):452-4. doi: 10.1038/533452a.
9
Evaluating replicability of laboratory experiments in economics.评估经济学实验室实验的可重复性。
Science. 2016 Mar 25;351(6280):1433-6. doi: 10.1126/science.aaf0918. Epub 2016 Mar 3.
10
PSYCHOLOGY. Estimating the reproducibility of psychological science.心理学. 心理科学可重复性的评估.
Science. 2015 Aug 28;349(6251):aac4716. doi: 10.1126/science.aac4716.
Zotero 插件