Danilenko Valery, Devyatkin Andrey, Marsova Mariya, Shibilova Madina, Ilyasov Rustem, Shmyrev Vladimir
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.
Central Clinical Hospital with a Polyclinic CMP RF, Moscow, Russia.
J Inflamm Res. 2021 Nov 30;14:6349-6381. doi: 10.2147/JIR.S333887. eCollection 2021.
In the last decade, metagenomic studies have shown the key role of the gut microbiome in maintaining immune and neuroendocrine systems. Malfunction of the gut microbiome can induce inflammatory processes, oxidative stress, and cytokine storm. Dysfunction of the gut microbiome can be caused by short-term (virus infection and other infectious diseases) or long-term (environment, nutrition, and stress) factors. Here, we reviewed the inflammation and oxidative stress in neurodegenerative diseases and coronavirus infection (COVID-19). Here, we reviewed the renin-angiotensin-aldosterone system (RAAS) involved in the processes of formation of oxidative stress and inflammation in viral and neurodegenerative diseases. Moreover, the coronavirus uses ACE2 receptors of the RAAS to penetrate human cells. The coronavirus infection can be the trigger for neurodegenerative diseases by dysfunction of the RAAS. Pharmabiotics, postbiotics, and next-generation probiotics, are considered as a means to prevent oxidative stress, inflammatory processes, neurodegenerative and viral diseases through gut microbiome regulation.
在过去十年中，宏基因组学研究表明肠道微生物群在维持免疫和神经内分泌系统方面发挥着关键作用。肠道微生物群功能失调可引发炎症过程、氧化应激和细胞因子风暴。肠道微生物群功能障碍可能由短期因素（病毒感染和其他传染病）或长期因素（环境、营养和压力）引起。在此，我们综述了神经退行性疾病和冠状病毒感染（COVID-19）中的炎症和氧化应激。在此，我们综述了肾素-血管紧张素-醛固酮系统（RAAS）在病毒和神经退行性疾病中氧化应激和炎症形成过程中的作用。此外，冠状病毒利用RAAS的ACE2受体进入人体细胞。冠状病毒感染可能通过RAAS功能障碍引发神经退行性疾病。药物益生菌、后生元及下一代益生菌被认为是通过调节肠道微生物群来预防氧化应激、炎症过程、神经退行性疾病和病毒疾病的一种手段。
