Drost Carolin Christina, Rovas Alexandros, Kümpers Philipp
Department of Medicine D, Division of General Internal and Emergency Medicine, Nephrology, and Rheumatology, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149 Münster, Germany.
Matrix Biol Plus. 2021 Nov 3;12:100091. doi: 10.1016/j.mbplus.2021.100091. eCollection 2021 Dec.
The endothelial glycocalyx (eGC), a delicate carbohydrate-rich structure lining the luminal surface of the vascular endothelium, is vital for maintenance of microvascular homeostasis. In sepsis, damage of the eGC triggers the development of vascular hyperpermeability with consecutive edema formation and organ failure. While there is evidence that protection or rebuilding of the eGC might counteract sepsis-induced vascular leakage and improve outcome, approved therapeutics are not yet available. This narrative review aims to outline possible therapeutic strategies to ameliorate organ dysfunction caused by eGC impairment.
内皮糖萼（eGC）是一种位于血管内皮腔面的富含碳水化合物的精细结构，对维持微血管稳态至关重要。在脓毒症中，eGC的损伤会引发血管通透性增加，继而形成水肿并导致器官功能衰竭。虽然有证据表明保护或重建eGC可能抵消脓毒症诱导的血管渗漏并改善预后，但目前尚未有获批的治疗方法。本叙述性综述旨在概述改善由eGC损伤引起的器官功能障碍的可能治疗策略。
