Moldofsky H, Lue F A, Eisen J, Keystone E, Gorczynski R M
Psychosom Med. 1986 May-Jun;48(5):309-18. doi: 10.1097/00006842-198605000-00001.
Serial sampling of peripheral blood from six healthy adult male volunteers was performed during daytime waking and nighttime sleeping. In addition, sleep physiology was assessed in all subjects (Ss) and sleep stages scored blind by standard criteria. Samples of plasma were analyzed for cortisol (Co) levels, functional interleukin-1 (IL-1), and interleukin-2 (IL-2) activity. Peripheral blood monocytes (PBM) were assayed to evaluate natural killer (NK) activity and mitogen responsiveness. Dramatic increase in IL-1 activity along with changes in other immune functions occurred during sleep and were related to onset of slow wave sleep.
在白天清醒和夜间睡眠期间，对6名健康成年男性志愿者进行了外周血的连续采样。此外，对所有受试者的睡眠生理学进行了评估，并根据标准标准对睡眠阶段进行了盲法评分。分析血浆样本中的皮质醇（Co）水平、功能性白细胞介素-1（IL-1）和白细胞介素-2（IL-2）活性。对外周血单核细胞（PBM）进行检测以评估自然杀伤（NK）活性和丝裂原反应性。睡眠期间IL-1活性显著增加，同时其他免疫功能也发生变化，且这些变化与慢波睡眠的开始有关。
