Hegde Nivedita, Ashwal A J, Deekonda Shrayva, Suresh K K
Department of Obstetrics and Gynaecology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Department of Cardiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Obstet Med. 2021 Dec;14(4):263-268. doi: 10.1177/1753495X20960906. Epub 2020 Oct 13.
Thiamine (vitamin B1) is a sulfur-containing, water-soluble vitamin that plays an essential role in energy metabolism and the tricarboxylic acid cycle. There is an increased need for vitamin B1 (1-1.2 mg daily) during pregnancy and lactation. Hyperemesis during pregnancy can cause severe polyneuropathy (Wernicke's encephalopathy) as a result of thiamine deficiency. Thiamine deficiency has also been associated with beriberi. A number of atypical cases with reversible right heart failure and severe pulmonary hypertension have also been reported in non-pregnant individuals, but have never been reported in pregnancy. Here we present five such cases of thiamine deficiency with neurological and cardio-pulmonary manifestations.
硫胺素（维生素B1）是一种含硫的水溶性维生素，在能量代谢和三羧酸循环中起着至关重要的作用。在怀孕和哺乳期，对维生素B1的需求量会增加（每日1-1.2毫克）。孕期的妊娠剧吐可因硫胺素缺乏导致严重的多发性神经病（韦尼克脑病）。硫胺素缺乏还与脚气病有关。在非妊娠个体中也有一些非典型的可逆性右心衰竭和严重肺动脉高压病例的报道，但在妊娠中从未有过报道。在此，我们介绍5例具有神经和心肺表现的硫胺素缺乏病例。
