Tan Mei L, Willis Christopher G
General Medicine, Khoo Teck Puat Hospital, Singapore, SGP.
Cureus. 2022 Jul 27;14(7):e27376. doi: 10.7759/cureus.27376. eCollection 2022 Jul.
Thiamine, also known as vitamin B1, plays a fundamental role in energy metabolism. The organs most sensitive to thiamine deficiency are the cardiovascular and nervous systems. The usual presentations include Wernicke's encephalopathy, polyneuropathy (known as "dry beriberi"), and the cardiovascular form (known as "wet beriberi"). Wet beriberi-induced acute severe pulmonary hypertension has rarely been previously described. Here we present a case of wet beriberi with severe right heart failure due to acute pulmonary hypertension. The underlying physiologic derangements dramatically improved after thiamine treatment. No other possible causes of pulmonary hypertension could be identified, with the exception of thiamine deficiency. This case illustrates the importance of considering wet beriberi as a possible cause of acute pulmonary hypertension with right heart failure.
硫胺素，又称维生素B1，在能量代谢中起着至关重要的作用。对硫胺素缺乏最敏感的器官是心血管系统和神经系统。常见表现包括韦尼克脑病、多发性神经病（称为“干性脚气病”）和心血管型（称为“湿性脚气病”）。湿性脚气病引起的急性严重肺动脉高压此前鲜有报道。在此，我们报告一例因急性肺动脉高压导致严重右心衰竭的湿性脚气病病例。硫胺素治疗后，潜在的生理紊乱显著改善。除硫胺素缺乏外，未发现其他可能导致肺动脉高压的原因。该病例说明了将湿性脚气病视为急性肺动脉高压伴右心衰竭的可能病因的重要性。
