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与饮食习惯相关的真菌群落组成及其对人类健康的影响。

Food Habit Associated Mycobiota Composition and Their Impact on Human Health.

作者信息

Shankar Jata

机构信息

Genomics Laboratory, Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Solan, India.

出版信息

Front Nutr. 2021 Nov 22;8:773577. doi: 10.3389/fnut.2021.773577. eCollection 2021.

Abstract

Mycobiota is not only associated with healthy homeostasis in the human gut but also helps to adapt to the environment. Food habits, alcohol consumption, intake of probiotics, and contaminated food with a mycotoxin, often lead to the alteration in the mycobiota composition. Impaired immunity of the host may affect fungal symbiosis leading to mycosis. The human gut adapts to the commensalism fungi belonging to the phylum Ascomycota and Basidiomycota. Diet habits such as plant-or animal-based, phytoestrogens enriched plant products, fat-rich diets also influence the colonization of certain fungal species in the mammalian gut. Food habits or mycotoxin-contaminated food or fungal peptides have an impact on bacterial-fungal interaction and human health. The mycobiota population such as , and are altered due to alcohol intake in alcoholic liver disease. The role of associated gut mycobiota due to irregular bowel habits or lifestyle change has been observed in inflammatory bowel disease. In this review, it has been observed that , and were the common genus in the human mycobiota. Therefore, this study focused on how diet habits and alcohol intake, among others., influence mycobiota composition that may affect the human immune system or overall health.

摘要

真菌群不仅与人体肠道内的健康稳态相关,还有助于适应环境。饮食习惯、酒精摄入、益生菌的摄取以及被霉菌毒素污染的食物,常常会导致真菌群组成的改变。宿主免疫力受损可能会影响真菌共生,进而引发真菌病。人体肠道会适应属于子囊菌门和担子菌门的共生真菌。诸如以植物或动物为基础的饮食习惯、富含植物雌激素的植物产品、高脂肪饮食等,也会影响某些真菌物种在哺乳动物肠道内的定殖。饮食习惯、被霉菌毒素污染的食物或真菌肽会对细菌 - 真菌相互作用及人类健康产生影响。在酒精性肝病中,诸如[此处原文缺失具体菌群名称]等真菌群数量会因酒精摄入而改变。在炎症性肠病中,已观察到因排便习惯不规律或生活方式改变而产生的相关肠道真菌群的作用。在本综述中,已观察到[此处原文缺失具体菌群名称]是人类真菌群中的常见属。因此,本研究聚焦于饮食习惯和酒精摄入等因素如何影响可能会影响人类免疫系统或整体健康的真菌群组成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e66c/8645600/0f85e4627567/fnut-08-773577-g0001.jpg

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