Modena V, Marengo C, Amoroso A, Rosina F, Costantini P, Bellando P, Coppo R, Rizzetto M
Clin Exp Rheumatol. 1986 Apr-Jun;4(2):129-34.
Clinical investigation of Primary Biliary Cirrhosis (PBC) patients showed an elevated frequency of rheumatic disorders, as well as their frequent appearance in asymptomatic PBC. Anticentromere region antibodies in PBC patients were pathognomonic for concomitant complete or incomplete CREST syndrome. These antibodies were only found on the HEp2 cell substrate. The constant finding of immune-complexes (IC) with IgM antibody component suggests that they play a role in the pathogenesis of PBC. No statistically significant correlation was found between the amount and classes of circulating IC, HLA class I antigens and rheumatic disorders during PBC.
原发性胆汁性肝硬化（PBC）患者的临床研究表明，风湿性疾病的发生率升高，且在无症状PBC患者中也经常出现。PBC患者的抗着丝粒区域抗体是伴随完全或不完全CREST综合征的特征性表现。这些抗体仅在HEp2细胞基质上发现。持续发现含有IgM抗体成分的免疫复合物（IC）表明它们在PBC的发病机制中起作用。在PBC期间，循环IC的数量和类别、HLA I类抗原与风湿性疾病之间未发现统计学上的显著相关性。
