Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Biochemistry and Clinical Laboratories, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
J Clin Lab Anal. 2022 Jan;36(1):e24170. doi: 10.1002/jcla.24170. Epub 2021 Dec 11.
Multiple sclerosis (MS) is a chronic inflammatory and autoimmune disease affecting various inflammatory and nutritional parameters. Therefore, this study aimed to investigate the relationship between the Body Mass Index (BMI) of MS patients and the serum levels of leptin, orexin-A, and Transforming Growth Factor β (TGF-β).
This cross-sectional study included 25 patients suffering from MS and 40 healthy individuals as the case and control groups, respectively. The serum levels of leptin, orexin-A, and TGF-β were assessed in the participants using the Enzyme-Linked Immunosorbent Assay methods. Moreover, data were analyzed using the descriptive statistical indices, t-test, chi-square test, and linear regression test.
According to our results, the participants' mean age was 38.04 ± 7.53 and 40.23 ± 5.88 in the case and control groups, respectively. Also, the groups were not significantly different in gender, age, alcohol consumption, and smoking (p > 0.05). It was found that the mean serum levels of orexin-A and TGF-β were significantly lower in the MS patients compared to the control group, while the mean serum leptin levels were significantly higher (42.8 vs. 18.9 ng/ml, p < 0.001). Moreover, there was no significant relationship between the BMI of the MS patients and their serum levels of orexin-A, TGF-β, and leptin (p > 0.05).
In conclusion, we found significantly lower levels of orexin-A and TGF-β and a significantly higher level of leptin in the MS patients compared to the control group. In addition, there was no significant relationship between the BMI and the serum levels of orexin-A, TGF-β, and leptin in MS patients.
多发性硬化症（MS）是一种影响多种炎症和营养参数的慢性炎症性自身免疫性疾病。因此，本研究旨在探讨 MS 患者的体重指数（BMI）与血清瘦素、食欲素-A 和转化生长因子-β（TGF-β）水平之间的关系。
本横断面研究纳入了 25 名 MS 患者和 40 名健康个体作为病例组和对照组。采用酶联免疫吸附试验方法检测参与者血清瘦素、食欲素-A 和 TGF-β水平。此外，采用描述性统计指标、t 检验、卡方检验和线性回归检验对数据进行分析。
根据我们的结果，病例组和对照组参与者的平均年龄分别为 38.04±7.53 和 40.23±5.88。此外，两组在性别、年龄、饮酒和吸烟方面无显著差异（p>0.05）。结果发现，MS 患者的血清食欲素-A 和 TGF-β水平明显低于对照组，而血清瘦素水平明显升高（42.8 与 18.9ng/ml，p<0.001）。此外，MS 患者的 BMI 与血清食欲素-A、TGF-β和瘦素水平之间无显著关系（p>0.05）。
总之，与对照组相比，MS 患者的血清食欲素-A 和 TGF-β水平明显较低，而瘦素水平明显较高。此外，MS 患者的 BMI 与血清食欲素-A、TGF-β和瘦素水平之间无显著关系。
