一种基于热可逆抗菌沸石的纳米颗粒负载水凝胶通过中和有害因子和清除活性氧来促进糖尿病伤口愈合。
A thermoreversible antibacterial zeolite-based nanoparticles loaded hydrogel promotes diabetic wound healing via detrimental factor neutralization and ROS scavenging.
作者信息
Qi Yao, Qian Kun, Chen Jin, E Yifeng, Shi Yijie, Li Hongdan, Zhao Liang
机构信息
School of Pharmacy, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
Department of Chemistry, Jinzhou Medical University, Jinzhou, 121000, People's Republic of China.
出版信息
J Nanobiotechnology. 2021 Dec 11;19(1):414. doi: 10.1186/s12951-021-01151-5.
BACKGROUND
As recovery time of diabetic wound injury is prolonged by the production of detrimental factors, including reactive oxygen species (ROS) and inflammatory cytokines, attenuating the oxidative stress and inflammatory reactions in the microenvironment of the diabetic wound site would be significant.
EXPERIMENTAL DESIGN
In our study, we prepared thermoreversible, antibacterial zeolite-based nanoparticles loaded hydrogel to promote diabetic wound healing via the neutralization of detrimental factors such as inflammatory cytokines and ROS.
RESULTS
The cerium (Ce)-doped biotype Linde type A (LTA) zeolite nanoparticles synergistically eliminated mitochondrial ROS and neutralized free inflammatory factors, thus remodeling the anti-inflammatory microenvironment of the wound and enhancing angiogenesis. Moreover, the thermoreversible hydrogel composed of Pluronic F127 and chitosan demonstrated strong haemostatic and bactericidal behavior.
CONCLUSIONS
In conclusion, the obtained thermoreversible, antibacterial, zeolite-based nanoparticles loaded hydrogels represent a multi-targeted combination therapy for diabetic wound healing.
背景
由于糖尿病伤口损伤的恢复时间因包括活性氧（ROS）和炎性细胞因子在内的有害因子的产生而延长，减轻糖尿病伤口部位微环境中的氧化应激和炎症反应具有重要意义。
实验设计
在我们的研究中，我们制备了基于热可逆、抗菌沸石的纳米颗粒负载水凝胶，以通过中和炎性细胞因子和ROS等有害因子来促进糖尿病伤口愈合。
结果
铈（Ce）掺杂的A型生物型林德（LTA）沸石纳米颗粒协同消除线粒体ROS并中和游离炎性因子，从而重塑伤口的抗炎微环境并促进血管生成。此外，由普朗尼克F127和壳聚糖组成的热可逆水凝胶表现出强大的止血和杀菌性能。
结论
总之，所获得的基于热可逆、抗菌沸石的纳米颗粒负载水凝胶代表了一种用于糖尿病伤口愈合的多靶点联合治疗方法。
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