School of Medicine and Health, Newcastle University, Newcastle upon Tyne, UK.
The School of Psychology, University of Sunderland, UK.
Vaccine. 2022 Jan 24;40(3):418-423. doi: 10.1016/j.vaccine.2021.11.090. Epub 2021 Dec 4.
The BNT162b2/Pfizer SARS-CoV-2 vaccine has been widely used in the UK, particularly amongst healthcare workers (HCWs). To establish whether previous COVID-19 influenced vaccine-associated Adverse Events (AEs), we conducted a survey-based study of HCWs in Northeast England. Out of 1238 HCWs, 32% self-reported prior positive PCR and/or antibody test for SARS-CoV-2. Post-dose AEs were worse in those with prior COVID-19 after the first, but not the second dose of vaccine. Second dose AEs were greater in frequency/severity, regardless of COVID-19 history, and they were more systemic in nature. Women and younger HCW were more likely to report AEs after both doses, while dosing interval had no effect on AEs. Ongoing Symptomatic COVID-19 was associated with greater frequency/severity of AEs after dose 2, but not dose one. Overall, AEs were self-limiting and short-lived (i.e.,<48 h) in nature. These findings have implications for vaccine hesitancy and informing guidelines for recommended dosing protocols.
辉瑞/BioNTech 的 SARS-CoV-2 疫苗在英国被广泛使用，特别是在医护人员（HCWs）中。为了确定之前的 COVID-19 是否影响疫苗相关的不良事件（AEs），我们在英格兰东北部对医护人员进行了一项基于调查的研究。在 1238 名医护人员中，32%的人自我报告先前的 SARS-CoV-2 阳性 PCR 和/或抗体检测。在第一剂和第二剂疫苗之后，有既往 COVID-19 史的人在接种后出现的不良事件更严重。第二剂疫苗的不良事件更频繁/更严重，无论 COVID-19 病史如何，且更具系统性。在两剂疫苗接种后，女性和年轻的 HCW 更有可能报告不良事件，而剂量间隔对不良事件没有影响。持续的有症状 COVID-19 与第二剂后不良事件的频率/严重程度增加有关，但与第一剂无关。总体而言，不良事件具有自限性和短暂性（即<48 小时）。这些发现对疫苗犹豫和为推荐的剂量方案提供指导方针具有重要意义。
