Physics Institute of São Carlos, São Paulo University, São Carlos, SP, Brazil.
Physics Institute of São Carlos, São Paulo University, São Carlos, SP, Brazil.
Colloids Surf B Biointerfaces. 2022 Feb;210:112254. doi: 10.1016/j.colsurfb.2021.112254. Epub 2021 Nov 29.
Nanomaterials have emerged as promising candidates for cancer therapy and diagnosis as they can solve long-term issues such as drug solubility, systemic distribution, tumor acquired resistance, and improve the performance of diagnostic methods. Among inorganic nanomaterials, AgNPs have been extensively studied in the context of cancer treatment and the reported results have raised exciting expectations. In this review, we provide an overview of the recent research on AgNPs antitumoral properties, their application in different cancer treatment modalities, their potential in biosensors development, and also highlight the main challenges and possible strategies to enable its translation to clinical use.
纳米材料作为癌症治疗和诊断的有前途的候选物已经出现,因为它们可以解决长期存在的问题,如药物溶解度、系统分布、肿瘤获得性耐药性,并提高诊断方法的性能。在无机纳米材料中,AgNPs 在癌症治疗方面的研究得到了广泛的研究,其报道的结果引起了人们的极大期望。在这篇综述中,我们概述了最近关于 AgNPs 抗肿瘤特性的研究,它们在不同癌症治疗方式中的应用,它们在生物传感器开发中的潜力,并强调了实现其向临床应用转化的主要挑战和可能的策略。