Nano Bio Electronic Devices Lab, Cancer Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran.
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
J Pharm Biomed Anal. 2022 Feb 5;209:114488. doi: 10.1016/j.jpba.2021.114488. Epub 2021 Nov 29.
Here for the first time, a real-time electrochemical assay on unprocessed blood was designed to detect the presence of cancer in patients. The system has been based on the recently approved pathway, which indicates that the abundance of immature and mature low-density neutrophils (LDNs) with reduced ROS production in peripheral blood is increased with the presence of active cancer tumors. Reduced ROS/HO released from LDNs play the main role in determining the ROS/HO levels of peripheral blood. In contrast, HDNs with increased levels of released ROS/HO have higher concentrations than LDNs in normal cases. Hence, the reduced level of ROS species in peripheral blood recorded by our carbon nanostructure decorated sensor in less than 30 seconds showed a great pre-warning about the presence of non-treated cancer in patients with suspicious mass who have been sent for further evaluations.
这是首次设计的一种基于实时电化学分析的方法，用于检测未经处理的血液中是否存在癌症。该系统是基于最近批准的途径，该途径表明，外周血中成熟和不成熟的低ROS 产生的低密度中性粒细胞（LDN）的丰度随着活性癌肿瘤的存在而增加。LDN 释放的减少的 ROS/HO 起决定外周血中 ROS/HO 水平的主要作用。相比之下，在正常情况下，具有更高释放 ROS/HO 水平的 HDN 的浓度比 LDN 更高。因此，我们的碳纳米结构修饰传感器在不到 30 秒的时间内记录到的外周血中 ROS 种类的减少水平，对疑似有肿块的患者的未经治疗的癌症的存在提供了很好的预警，这些患者已被送往进一步评估。
