Jeon Junhyun, Lee Song Hee
Department of Biotechnology, College of Life and Applied Sciences, Yeungnam University, Gyeongsan 38541, Korea.
Plant Immunity Center, Seoul National University, Seoul 08826, Korea.
Plant Pathol J. 2021 Dec;37(6):505-511. doi: 10.5423/PPJ.RW.07.2021.0111. Epub 2021 Dec 1.
Interaction of a pathogen with its host plant requires both flexibility and rapid shift in gene expression programs in response to environmental cues associated with host cells. Recently, a growing volume of data on the diversity and ubiquity of internal RNA modifications has led to the realization that such modifications are highly dynamic and yet evolutionarily conserved system. This hints at these RNA modifications being an additional regulatory layer for genetic information, culminating in epitranscriptome concept. In plant pathogenic fungi, however, the presence and the biological roles of RNA modifications are largely unknown. Here we delineate types of RNA modifications, and provide examples demonstrating roles of such modifications in biology of filamentous fungi including fungal pathogens. We also discuss the possibility that RNA modification systems in fungal pathogens could be a prospective target for new agrochemicals.
病原体与其宿主植物的相互作用需要灵活性，并且基因表达程序要根据与宿主细胞相关的环境线索进行快速转变。最近，关于内部RNA修饰的多样性和普遍性的大量数据表明，这些修饰是一个高度动态但在进化上保守的系统。这暗示这些RNA修饰是遗传信息的额外调控层，最终形成了表观转录组的概念。然而，在植物病原真菌中，RNA修饰的存在及其生物学作用在很大程度上尚不清楚。在这里，我们描述了RNA修饰的类型，并提供实例说明这些修饰在丝状真菌（包括真菌病原体）生物学中的作用。我们还讨论了真菌病原体中的RNA修饰系统可能成为新型农用化学品潜在靶点的可能性。
