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乳腺癌管理和细胞外囊泡研究进展的文献计量分析。

Advances in Breast Cancer Management and Extracellular Vesicle Research, a Bibliometric Analysis.

机构信息

Laboratory of Tumor Microenvironment, Department of Cell and Developmental Biology, Institute of Biomedical Sciences (ICB), University of São Paulo, São Paulo 05508-000, Brazil.

Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, 97080 Würzburg, Germany.

出版信息

Curr Oncol. 2021 Nov 8;28(6):4504-4520. doi: 10.3390/curroncol28060382.

DOI:10.3390/curroncol28060382
PMID:34898576
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8628791/
Abstract

Extracellular vesicles transport variable content and have crucial functions in cell-cell communication. The role of extracellular vesicles in cancer is a current hot topic, and no bibliometric study has ever analyzed research production regarding their role in breast cancer and indicated the trends in the field. In this way, we aimed to investigate the trends in breast cancer management involved with extracellular vesicle research. Articles were retrieved from Scopus, including all the documents published concerning breast cancer and extracellular vesicles. We analyzed authors, journals, citations, affiliations, and keywords, besides other bibliometric analyses, using R Studio version 3.6.2. and VOSviewer version 1.6.0. A total of 1151 articles were retrieved, and as the main result, our analysis revealed trending topics on biomarkers of liquid biopsy, drug delivery, chemotherapy, autophagy, and microRNA. Additionally, research related to extracellular vesicles in breast cancer has been focused on diagnosis, treatment, and mechanisms of action of breast tumor-derived vesicles. Future studies are expected to explore the role of extracellular vesicles on autophagy and microRNA, besides investigating the application of extracellular vesicles from liquid biopsies for biomarkers and drug delivery, enabling the development and validation of therapeutic strategies for specific cancers.

摘要

细胞外囊泡携带可变的内容物，在细胞间通讯中具有关键功能。细胞外囊泡在癌症中的作用是当前的热门话题，尚无文献计量学研究分析过它们在乳腺癌中的作用，并指出该领域的趋势。为此，我们旨在研究与细胞外囊泡研究相关的乳腺癌管理趋势。文章从 Scopus 中检索，包括所有关于乳腺癌和细胞外囊泡的已发表文献。我们使用 R Studio 版本 3.6.2 和 VOSviewer 版本 1.6.0 分析了作者、期刊、引文、隶属关系和关键词等其他文献计量学分析。共检索到 1151 篇文章，作为主要结果，我们的分析揭示了液体活检、药物输送、化疗、自噬和 microRNA 等生物标志物的研究趋势。此外，关于乳腺癌中细胞外囊泡的研究主要集中在乳腺癌来源的囊泡的诊断、治疗和作用机制上。未来的研究有望探索细胞外囊泡在自噬和 microRNA 中的作用，以及研究液体活检中外泌体在生物标志物和药物输送中的应用，从而为特定癌症的治疗策略的开发和验证提供支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/0efa6a7c636c/curroncol-28-00382-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/b50563da11e2/curroncol-28-00382-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/7236f099ed45/curroncol-28-00382-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/92ffa588b28f/curroncol-28-00382-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/800ade764836/curroncol-28-00382-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/573b67d16cfd/curroncol-28-00382-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/0efa6a7c636c/curroncol-28-00382-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/b50563da11e2/curroncol-28-00382-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/7236f099ed45/curroncol-28-00382-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/92ffa588b28f/curroncol-28-00382-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/800ade764836/curroncol-28-00382-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/573b67d16cfd/curroncol-28-00382-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2419/8628791/0efa6a7c636c/curroncol-28-00382-g006.jpg

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