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人类嗜T淋巴细胞病毒III型（HTLV-III/LAV）3' 开放阅读框区域内突变对复制及细胞致病性的影响。

Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity.

作者信息

Terwilliger E, Sodroski J G, Rosen C A, Haseltine W A

出版信息

J Virol. 1986 Nov;60(2):754-60. doi: 10.1128/JVI.60.2.754-760.1986.

DOI:10.1128/JVI.60.2.754-760.1986
PMID:3490583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC288951/
Abstract

Mutations that eliminated the ability of the human T-cell lymphotropic virus type III to produce the 27-kilodalton 3' orf product did not eliminate the ability of the virus to replicate in and kill T4+ cells. A mutant carrying a mutation that deleted carboxy-terminal sequences from the envelope gene as well as the 3' orf sequences retained the ability to kill T4+ lymphocytes, but had a retarded replication rate.

摘要

消除人类III型嗜T细胞病毒产生27千道尔顿3' 开放阅读框产物能力的突变，并未消除该病毒在T4+细胞中复制及杀伤T4+细胞的能力。一个携带突变的突变体，该突变删除了包膜基因的羧基末端序列以及3' 开放阅读框序列，仍保留杀伤T4+淋巴细胞的能力，但复制速率减慢。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/419c/288951/3f24e6911538/jvirol00168-0430-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/419c/288951/37a061b9eb6b/jvirol00168-0430-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/419c/288951/3f24e6911538/jvirol00168-0430-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/419c/288951/37a061b9eb6b/jvirol00168-0430-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/419c/288951/3f24e6911538/jvirol00168-0430-b.jpg

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