Behzadi Payam, Gajdács Márió
1 Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, 37541-374, Iran.
2 Department of Oral Biology and Experimental Dental Research, Faculty of Dentistry, University of Szeged, 6720, Szeged, Hungary.
Eur J Microbiol Immunol (Bp). 2021 Dec 15;11(4):77-86. doi: 10.1556/1886.2021.00020. Print 2022 Feb 3.
The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RSCB PDB) provides a wide range of digital data regarding biology and biomedicine. This huge internet resource involves a wide range of important biological data, obtained from experiments around the globe by different scientists. The Worldwide Protein Data Bank (wwPDB) represents a brilliant collection of 3D structure data associated with important and vital biomolecules including nucleic acids (RNAs and DNAs) and proteins. Moreover, this database accumulates knowledge regarding function and evolution of biomacromolecules which supports different disciplines such as biotechnology. 3D structure, functional characteristics and phylogenetic properties of biomacromolecules give a deep understanding of the biomolecules' characteristics. An important advantage of the wwPDB database is the data updating time, which is done every week. This updating process helps users to have the newest data and information for their projects. The data and information in wwPDB can be a great support to have an accurate imagination and illustrations of the biomacromolecules in biotechnology. As demonstrated by the SARS-CoV-2 pandemic, rapidly reliable and accessible biological data for microbiology, immunology, vaccinology, and drug development are critical to address many healthcare-related challenges that are facing humanity. The aim of this paper is to introduce the readers to wwPDB, and to highlight the importance of this database in biotechnology, with the expectation that the number of scientists interested in the utilization of Protein Data Bank's resources will increase substantially in the coming years.
结构生物信息学蛋白质数据库研究协作实验室（RSCB PDB）提供了大量有关生物学和生物医学的数字数据。这个庞大的互联网资源包含了广泛的重要生物数据，这些数据是由全球不同科学家通过实验获得的。全球蛋白质数据库（wwPDB）是与包括核酸（RNA和DNA）和蛋白质在内的重要生物分子相关的三维结构数据的杰出集合。此外，该数据库积累了有关生物大分子功能和进化的知识，支持生物技术等不同学科。生物大分子的三维结构、功能特性和系统发育特性有助于深入了解生物分子的特征。wwPDB数据库的一个重要优势是数据更新时间，每周都会进行更新。这个更新过程帮助用户在项目中获取最新的数据和信息。wwPDB中的数据和信息对于在生物技术中准确想象和描绘生物大分子有很大帮助。正如新冠疫情所表明的，快速、可靠且可获取的微生物学、免疫学、疫苗学和药物开发生物学数据对于应对人类面临的许多与医疗保健相关的挑战至关重要。本文旨在向读者介绍wwPDB，并强调该数据库在生物技术中的重要性，期望未来几年对利用蛋白质数据库资源感兴趣的科学家数量将大幅增加。
