Obeid Maram Farouk, El-Batouty Kareim Moustafa, Aslam Mohammed
Department of Endodontic, Faculty of Dentistry, Ain Shams University, Cairo, Egypt.
Restor Dent Endod. 2021 Oct 29;46(4):e58. doi: 10.5395/rde.2021.46.e58. eCollection 2021 Nov.
This study addresses the effect of using nanoparticles (np) on the antimicrobial properties of bioactive glass (BAG) when used in intracanal medicaments against () biofilms.
biofilms, grown inside 90 root canals for 21 days, were randomly divided into 4 groups according to the antimicrobial regimen followed ( = 20; BAG-np, BAG, calcium hydroxide [CaOH], and saline). After 1 week, residual live bacteria were quantified in terms of colony-forming units (CFU), while dead bacteria were assessed with a confocal laser scanning microscope.
Although there was a statistically significant decrease in the mean CFU value among all groups, the nano-group performed the best. The highest percentage of dead bacteria was detected in the BAG-np group, with a significant difference from the BAG group.
The reduction of particle size and use of a nano-form of BAG improved the antimicrobial properties of the intracanal treatment of biofilms.
本研究探讨了纳米颗粒（np）对生物活性玻璃（BAG）用作根管内药物对抗（）生物膜时抗菌性能的影响。
在90个根管内生长21天的生物膜，根据所采用的抗菌方案随机分为4组（每组n = 20；BAG-np组、BAG组、氢氧化钙[CaOH]组和生理盐水组）。1周后，以菌落形成单位（CFU）对残留活菌进行定量，同时用共聚焦激光扫描显微镜评估死菌。
尽管所有组的平均CFU值均有统计学意义的下降，但纳米组表现最佳。在BAG-np组中检测到的死菌百分比最高，与BAG组有显著差异。
减小BAG颗粒尺寸并使用纳米形式可改善根管内治疗生物膜的抗菌性能。
