Viswam Vijay, Dragas Jelena, Shadmani Amir, Chen Yihui, Stettler Alexander, Müller Jan, Hierlemann Andreas
ETH Zurich, Basel, Switzerland.
Dig Tech Pap IEEE Int Solid State Circuits Conf. 2016 Feb 25;2016:394-396. doi: 10.1109/ISSCC.2016.7418073.
Various CMOS-based micro-electrode arrays (MEAs) have been developed in recent years for extracellular electrophysiological recording/stimulation of electrogenic cells [1-5]. Mostly two approaches have been used: (i) the activepixel approach (APS) [2-4], which features simultaneous readout of all electrodes, however, at the expense of a comparably high noise level, and (ii) the switchmatrix (SM) approach, which yields better noise performance, whereas only a subset of electrodes (e.g.,1024) is simultaneously read out [5]. All systems feature, at most, voltage recording and/or voltage/current stimulation functionalities.
近年来，人们开发了各种基于互补金属氧化物半导体（CMOS）的微电极阵列（MEA），用于对电活性细胞进行细胞外电生理记录/刺激[1-5]。主要采用了两种方法：（i）有源像素方法（APS）[2-4]，其特点是可以同时读出所有电极，但代价是噪声水平相对较高；（ii）开关矩阵（SM）方法，其噪声性能更好，但同时只能读出一部分电极（例如1024个）[5]。所有系统最多具备电压记录和/或电压/电流刺激功能。
