Ceglarek Anna, Ochab Jeremi K, Cifre Ignacio, Fafrowicz Magdalena, Sikora-Wachowicz Barbara, Lewandowska Koryna, Bohaterewicz Bartosz, Marek Tadeusz, Chialvo Dante R
Department of Cognitive Neuroscience and Neuroergonomics, Institute of Applied Psychology, Jagiellonian University, Krakow, Poland.
M. Kac Complex Systems Research Center and M. Smoluchowski Institute of Physics, Jagiellonian University, Krakow, Poland.
Front Neurosci. 2021 Dec 3;15:778242. doi: 10.3389/fnins.2021.778242. eCollection 2021.
Recent works shed light on the neural correlates of true and false recognition and the influence of time of day on cognitive performance. The current study aimed to investigate the modulation of the false memory formation by the time of day using a non-linear correlation analysis originally designed for fMRI resting-state data. Fifty-four young and healthy participants (32 females, mean age: 24.17 ± 3.56 y.o.) performed in MR scanner the modified Deese-Roediger-McDermott paradigm in short-term memory during one session in the morning and another in the evening. Subjects' responses were modeled with a general linear model, which includes as a predictor the non-linear correlations of regional BOLD activity with the stimuli, separately for encoding and retrieval phases. The results show the dependence of the non-linear correlations measures with the time of day and the type of the probe. In addition, the results indicate differences in the correlations measures with hippocampal regions between positive and lure probes. Besides confirming previous results on the influence of time-of-day on cognitive performance, the study demonstrates the effectiveness of the non-linear correlation analysis method for the characterization of fMRI task paradigms.
近期的研究揭示了真实和错误识别的神经关联以及一天中的不同时间对认知表现的影响。本研究旨在使用最初为功能磁共振成像静息态数据设计的非线性相关分析，探讨一天中的不同时间对错误记忆形成的调节作用。54名年轻健康的参与者（32名女性，平均年龄：24.17±3.56岁）在上午和晚上各进行一次磁共振扫描，期间在短期记忆中执行改良的Deese-Roediger-McDermott范式。用一般线性模型对受试者的反应进行建模，该模型将区域血氧水平依赖（BOLD）活动与刺激的非线性相关性作为预测因子，分别用于编码和检索阶段。结果显示非线性相关测量值与一天中的时间以及探测类型有关。此外，结果表明正向和诱饵探测在与海马区的相关性测量上存在差异。除了证实先前关于一天中的时间对认知表现影响的结果外，该研究还证明了非线性相关分析方法在功能磁共振成像任务范式表征中的有效性。
