The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, China.
Department of Infectious Diseases Treatment, Wuhan Medical Treatment Center, Wuhan, China.
Front Cell Infect Microbiol. 2021 Dec 1;11:781246. doi: 10.3389/fcimb.2021.781246. eCollection 2021.
Reports on alterations in the oral mycobiome of HIV-infected patients are still limited. This study was designed to compare the salivary mycobiome between 30 human immunodeficiency virus (HIV) infections and 30 healthy controls and explore the effect of antiretroviral therapy (ART) administration on the oral mycobiome of HIV infections. Results showed that the diversity and richness of salivary mycobiome in HIV-infected individuals were higher than those of controls ( < 0.05). After ART, the diversity and richness of salivary mycobiome in HIV-infected patients were reduced significantly ( < 0.05). , , , , and were significantly enriched in the HIV group and dramatically decreased after ART. While the relative abundance of , , and significantly increased in patients with HIV after ART. Correlation analysis revealed that , , , and were positively correlated with viral load (VL), whereas and were negatively related to VL and positively related to CD4 T-cell counts. All results showed that HIV infection and ART administration affected the composition of salivary mycobiome communities. Furthermore, differences of salivary mycobiome in HIV infections after ART were complex and might mirror the immune state of the body.
HIV 感染者口腔微生物组的变化报告仍然有限。本研究旨在比较 30 例人类免疫缺陷病毒（HIV）感染患者和 30 例健康对照者的唾液微生物组，并探讨抗逆转录病毒治疗（ART）对 HIV 感染者口腔微生物组的影响。结果表明，HIV 感染者唾液微生物组的多样性和丰富度高于对照组（<0.05）。ART 后，HIV 感染者唾液微生物组的多样性和丰富度显著降低（<0.05）。、、、和在 HIV 组中明显富集，ART 后显著减少。而在 ART 后，HIV 患者的、和相对丰度显著增加。相关性分析显示、、和与病毒载量（VL）呈正相关，而和与 VL 呈负相关，与 CD4 T 细胞计数呈正相关。所有结果表明，HIV 感染和 ART 治疗影响唾液微生物组群落的组成。此外，ART 后 HIV 感染者唾液微生物组的差异复杂，可能反映了机体的免疫状态。
