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天然产物作为潜在的抗病毒药物:海洋生物毒素的具体情况

Natural Products as Potential Antiviral Drugs: The Specific Case of Marine Biotoxins.

机构信息

Institut de Biologie du Développement de Marseille (IBDM), UMR-7288 CNRS Aix-Marseille University, 13288 Marseille Cedex, France.

出版信息

Russ J Bioorg Chem. 2021;47(6):1127-1132. doi: 10.1134/S1068162021060133. Epub 2021 Dec 16.

Abstract

To fight against various viral infections researchers turned to new chemical structures resulting from natural medicinal plants and more recently from "marine origin" as sources of active molecules against viral infections. The present manuscript describes complex marine origin drugs, their chemical complex structure, their therapeutic use, and their antiviral properties. Emphasis is placed more particularly on the properties of ionic channels (Na, K, Ca) blockers compounds from marine origin, named , derived from "dinoflagellates microalgae". These compounds are of particular pharmaceutical interest since could be used to fight against a wide diversity of viruses, including SARS-CoV2 virus.

摘要

为了对抗各种病毒感染,研究人员转向了源自天然药用植物以及最近源自“海洋来源”的新化学结构,将其作为对抗病毒感染的活性分子来源。本手稿描述了复杂的海洋来源药物、它们的化学复杂结构、它们的治疗用途以及它们的抗病毒特性。特别强调了源自海洋的离子通道(钠、钾、钙)阻滞剂化合物的特性,这些化合物名为 ,源自“甲藻微藻”。这些化合物具有特殊的药学意义,因为 可用于对抗多种病毒,包括新型冠状病毒。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a832/8675108/0edc5c1386c0/11171_2021_8379_Fig1_HTML.jpg

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