Illian Didi Nurhadi, Siregar Etti Sartina, Sumaiyah Sumaiyah, Utomo Ahmad Rusdan, Nuryawan Arif, Basyuni Mohammad
Department of Pharmacy, Faculty of Mathematics and Natural Science, Universitas Syiah Kuala, Banda Aceh, 23111, Indonesia.
Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, 20155, Indonesia.
Heliyon. 2021 Jan;7(1):e06001. doi: 10.1016/j.heliyon.2021.e06001. Epub 2021 Jan 16.
The outbreak of coronaviruses (CoVs) presents an enormous threat to humans. To date, no new therapeutic drugs or vaccines licensed to treat human coronaviruses remain undiscovered. This mini-review briefly reports the number of potential plants widely distributed in Indonesia for further research and development as anti-SARS-CoV-2 agents and the critical targets for SARS-CoV-2 therapy, such as angiotensin-converting enzyme 2 (ACE-2) receptor, spike protein, 3-chymotrypsin-like protease (3CL), papain-like protease (PL), RNA-dependent RNA polymerase (RdRp), helicase, and serine protease. Indonesia is rich in medicinal plants (herbal); it also has a long history of using plants to treat various hereditary diseases. However, since SARS-CoV-2 is a new disease, it has no history of plant-based treatment anywhere in the world. This mini-review describes natural products from several Indonesian plants that contain compounds that could potentially prevent or reduce SARS-CoV-2 infection, act as potential targeted therapy, and provide new therapeutic strategies to develop SARS-CoV-2 countermeasures.
冠状病毒（CoVs）的爆发对人类构成了巨大威胁。迄今为止，尚未发现新的已获许可用于治疗人类冠状病毒的治疗药物或疫苗。这篇小型综述简要报告了在印度尼西亚广泛分布的具有潜力的植物数量，以便作为抗SARS-CoV-2药物进行进一步研发，还介绍了SARS-CoV-2治疗的关键靶点，如血管紧张素转换酶2（ACE-2）受体、刺突蛋白、3-糜蛋白酶样蛋白酶（3CL）、木瓜蛋白酶样蛋白酶（PL）、RNA依赖性RNA聚合酶（RdRp）、解旋酶和丝氨酸蛋白酶。印度尼西亚富含药用植物（草药）；该国还有使用植物治疗各种遗传性疾病的悠久历史。然而，由于SARS-CoV-2是一种新疾病，在世界任何地方都没有基于植物的治疗历史。这篇小型综述描述了几种印度尼西亚植物的天然产物，这些植物含有可能预防或减少SARS-CoV-2感染的化合物，可作为潜在的靶向治疗药物，并为开发对抗SARS-CoV-2的对策提供新的治疗策略。
