Sanclemente Gloria, Hernandez Natalia, Chaparro Daniela, Tamayo Liliana, Lopez Angela
Group of Investigative Dermatology (GRID), University of Antioquia, Medellín, Colombia.
Dermatosoluciones SAS, Calle 90 # 19A 49 Cons 501, Bogotá, Colombia.
World Allergy Organ J. 2021 Dec 6;14(12):100611. doi: 10.1016/j.waojou.2021.100611. eCollection 2021 Dec.
Atopic dermatitis (AD) is considered as one of the most frequent chronic skin conditions. Previous AD epidemiologic studies have been mainly retrospective and/or have been performed through surveys instead of in-person visits. Epidemiological studies concerning AD in Latin American countries are scarce.
To describe sociodemographic and clinical features and the economic burden of AD on children and adult patients in Colombia through in-person visits.
This was a cross-sectional study of 212 patients that included sociodemographic and clinimetric data. The diagnostic criteria of Hanifin and Rajka was used and data relating to disease distribution, disease severity (through the BSA: Body surface area; EASI: Eczema Area and Severity Index; SCORAD: Scoring Atopic Dermatitis), Fitzpatrick's skin phototypes, personal and familiar history of allergic diseases, previous treatments, and personal history of comorbidities, was collected.
Patient age range was 12-76, and 52.8% were female. Disease distribution was mainly flexural (19.6%). Early age start, Denni-Morgan fold, and infections tendency were more frequent in adolescents compared to adults. Mean age of diagnosis was 12 years old, AD diagnosis was made mostly by a dermatologist, 48.1% (102 patients) reported alcohol consumption, and 59% of consumers were heavy drinkers. Comorbidities found were: chronic rhinitis (68.9%) food allergy (32.5%), allergic conjunctivitis (29.7%), and asthma (28.8%). Around 81% earned less than $896 US dollars and 59% invested 6-30% of their monthly budget yearly, and 40% had work or school absenteeism. Mean scores of BSA, EASI, and SCORAD involvement were 32.6, 13.7, and 42.4, respectively.
This study adds well-supported data through an in-depth clinical and economical characterization of Colombian adolescents and adult patients with atopic dermatitis and shows its high impact and burden on patients and their families. It also contributes to understand the burden of AD in Latin America.
特应性皮炎（AD）被认为是最常见的慢性皮肤病之一。以往的AD流行病学研究主要是回顾性的，和/或通过调查而非面对面访视进行。拉丁美洲国家关于AD的流行病学研究较少。
通过面对面访视描述哥伦比亚儿童和成年患者AD的社会人口学和临床特征以及经济负担。
这是一项对212例患者的横断面研究，包括社会人口学和临床测量数据。采用Hanifin和Rajka的诊断标准，收集有关疾病分布、疾病严重程度（通过体表面积[BSA]、湿疹面积和严重程度指数[EASI]、特应性皮炎评分[SCORAD]）、Fitzpatrick皮肤光类型、个人和家族过敏疾病史、既往治疗以及合并症个人史的数据。
患者年龄范围为12至76岁，52.8%为女性。疾病分布主要在屈侧（19.6%）。与成年人相比，青少年发病年龄早、有丹尼 - 摩根皱襞和感染倾向更为常见。平均诊断年龄为12岁，AD诊断大多由皮肤科医生做出，48.1%（102例患者）报告饮酒，其中59%为重度饮酒者。发现的合并症有：慢性鼻炎（68.9%）、食物过敏（32.5%）、过敏性结膜炎（29.7%）和哮喘（28.8%）。约81%的人收入低于896美元，59%的人每年将月预算的6 - 30%用于此，40%的人有工作或学校缺勤情况。BSA、EASI和SCORAD受累的平均评分分别为32.6、13.7和42.4。
本研究通过对哥伦比亚青少年和成年特应性皮炎患者进行深入的临床和经济特征分析，提供了有力的数据支持，显示了其对患者及其家庭的高度影响和负担。它也有助于了解拉丁美洲AD的负担。
