Grupo de Investigación Dermatológica, Universidad de Antioquia, Medellín, Colombia y Grupo de Innovación y Desarrollo en Investigación - CIC, Medellin, Colombia; Dermatologia, Hospital San Vicente Fundación-IPS Universitaria, Universidad de Antioquia, Medellín, Colombia.
Dermatosoluciones SAS, Bogotá, D.C., Colombia.
Biomedica. 2024 Aug 29;44(3):318-327. doi: 10.7705/biomedica.6998.
Reports regarding the correlation and effect size of change of the full spectrum of quality of life and disease severity measures applied in-person to patients with atopic dermatitis are scarce.
To assess quality-of-life with 3 different instruments and to evaluate disease severity indices and to determine their correlation and effect size of change between two measurements.
Patient-level data were obtained through two in-person visits. Sociodemographic information and data related to disease distribution, severity (through the BSA, EASI, SCORAD, POEM, and itching scales), and the impact of atopic dermatitis on quality of life using the DLQI and Skindex-29, and EQ-5D, were assessed. The correlation between change in quality-of-life scores and disease severity scores in addition to the standardized effect size were also evaluated.
Only 139 out of 212 patients completed the follow-up visit. BSA highly correlated with SCORAD and EASI, and the lowest correlation was found with POEM. The best correlation of pruritus VAS was found with sleep disturbance. The SCORAD score highly correlated with EASI, and the lowest correlation was found with POEM. The magnitude of the effect at initiation of the study vs follow-up was in average moderate to important.
Patients with atopic dermatitis experience a substantial burden on quality of life. Disease activity correlates better with quality-of-life measurements when the disease is less severe after starting therapy. POEM and Skindex-29 seem to be optimal to determine disease severity and quality of life in adults with atopic dermatitis.
有关特应性皮炎患者亲自接受评估的全谱生活质量和疾病严重程度措施的相关性和变化效应大小的报告很少。
使用 3 种不同的工具评估生活质量，并评估疾病严重程度指数，并确定两次测量之间的相关性和变化效应大小。
通过两次亲自就诊获得患者水平数据。评估了社会人口统计学信息以及与疾病分布、严重程度（通过 BSA、EASI、SCORAD、POEM 和瘙痒量表）以及特应性皮炎对生活质量的影响相关的数据，使用 DLQI 和 Skindex-29 以及 EQ-5D 进行评估。还评估了生活质量评分变化与疾病严重程度评分之间的相关性以及标准化效应大小。
只有 212 名患者中的 139 名完成了随访。BSA 与 SCORAD 和 EASI 高度相关，与 POEM 的相关性最低。瘙痒 VAS 的最佳相关性是与睡眠障碍相关。SCORAD 评分与 EASI 高度相关，与 POEM 的相关性最低。研究开始时与随访时的效应大小均为中度至重要。
特应性皮炎患者的生活质量负担很大。在开始治疗后疾病活动度较轻时，疾病活动度与生活质量测量的相关性更好。POEM 和 Skindex-29 似乎是确定特应性皮炎成人疾病严重程度和生活质量的最佳选择。
