Russell Madisen T, Funsch Kensie M, Springfield Cassi R, Ackerman Robert A, Depp Colin A, Harvey Philip D, Moore Raeanne C, Pinkham Amy E
Department of Psychology, University of Texas at Dallas, 800 W. Campbell Rd., Richardson, TX 75080, United States of America.
Department of Psychiatry, University of California San Diego, 9500 Gilman Dr., La Jolla, CA, 92093, United States of America.
Schizophr Res Cogn. 2021 Dec 2;27:100226. doi: 10.1016/j.scog.2021.100226. eCollection 2022 Mar.
The MATRICS Consensus Cognitive Battery (MCCB) is a gold-standard tool for assessing cognitive functioning in individuals with severe mental illness. This study is an initial examination of the validity of remote administration of 4 MCCB tests measuring processing speed (Trail Making Test: Part A, Animal Fluency), working memory (Letter-Number Span), and verbal learning and memory (Hopkins Verbal Learning Test-Revised). We conducted analyses on individuals with bipolar disorder (BD) and schizophrenia-spectrum disorders (SCZ), as well as healthy volunteers, who were assessed in-person (BD = 80, SCZ = 116, HV = 14) vs. remotely (BD = 93, SCZ = 43, HV = 30) to determine if there were significant differences in performance based on administration format. Additional analyses tested whether remote and in-person assessment performance was similarly correlated with symptom severity, cognitive and social cognitive performance, and functional outcomes. Individuals with BD performed significantly better than those with SCZ on all MCCB subtests across administration format. Animal Fluency did not differ by administration format, but remote participants performed significantly worse on Trail Making and HVLT-R. On the Letter-Number Span task, individuals with bipolar disorder performed significantly better when participating remotely. Finally, patterns of correlations with related constructs were largely similar between administration formats. Thus, results suggest that remote administration of some of the MCCB subtests may be a valid alternative to in-person testing, but more research is necessary to determine why some tasks were affected by administration format.
MATRICS共识认知成套测验（MCCB）是评估严重精神疾病患者认知功能的金标准工具。本研究初步检验了远程施测4项MCCB测验（测量加工速度的连线测验A部分、动物流畅性测验）、工作记忆（数字广度顺背倒背）以及言语学习与记忆（修订版霍普金斯言语学习测验）的效度。我们对双相情感障碍（BD）患者、精神分裂症谱系障碍（SCZ）患者以及健康志愿者进行了分析，这些受试者分别接受了面对面评估（BD = 80例，SCZ = 116例，HV = 14例）和远程评估（BD = 93例，SCZ = 43例，HV = 30例），以确定施测方式是否会导致测验表现出现显著差异。另外的分析检验了远程评估和面对面评估的表现与症状严重程度、认知及社会认知表现以及功能结局之间的相关性是否相似。在所有MCCB子测验中，无论施测方式如何，BD患者的表现均显著优于SCZ患者。动物流畅性测验的表现不因施测方式而异，但远程施测时，受试者在连线测验和修订版霍普金斯言语学习测验中的表现显著更差。在数字广度顺背倒背任务中，双相情感障碍患者远程参与时表现显著更好。最后，两种施测方式下与相关构念的相关模式大体相似。因此，结果表明，部分MCCB子测验的远程施测可能是面对面测试的有效替代方式，但仍需更多研究来确定为何有些任务会受到施测方式的影响。
