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基于磁共振成像的纳米复合弗里克凝胶剂量计快速映射法对碳离子束进行全三维剂量测定

Whole Three-Dimensional Dosimetry of Carbon Ion Beams with an MRI-Based Nanocomposite Fricke Gel Dosimeter Using Rapid Mapping Method.

作者信息

Mizukami Shinya, Watanabe Yusuke, Mizoguchi Takahiro, Gomi Tsutomu, Hara Hidetake, Takei Hideyuki, Fukunishi Nobuhisa, Ishikawa Kenichi L, Fukuda Shigekazu, Maeyama Takuya

机构信息

School of Allied Health Sciences, Kitasato University, Sagamihara 252-0373, Japan.

Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Japan.

出版信息

Gels. 2021 Nov 25;7(4):233. doi: 10.3390/gels7040233.

Abstract

MRI-based gel dosimeters are attractive systems for the evaluation of complex dose distributions in radiotherapy. In particular, the nanocomposite Fricke gel dosimeter is one among a few dosimeters capable of accurately evaluating the dose distribution of heavy ion beams. In contrast, reduction of the scanning time is a challenging issue for the acquisition of three-dimensional volume data. In this study, we investigated a three-dimensional dose distribution measurement method for heavy ion beams using variable flip angle (VFA), which is expected to significantly reduce the MRI scanning time. Our findings clarified that the whole three-dimensional dose distribution could be evaluated within the conventional imaging time (20 min) and quality of one cross-section.

摘要

基于磁共振成像(MRI)的凝胶剂量计是用于评估放射治疗中复杂剂量分布的有吸引力的系统。特别是,纳米复合弗里克凝胶剂量计是少数能够准确评估重离子束剂量分布的剂量计之一。相比之下,减少扫描时间是获取三维体积数据面临的一个具有挑战性的问题。在本研究中,我们研究了一种使用可变翻转角(VFA)测量重离子束三维剂量分布的方法,该方法有望显著减少MRI扫描时间。我们的研究结果表明,在传统成像时间(20分钟)内以及一个横截面的质量范围内,可以评估整个三维剂量分布。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c83/8701283/c2677c825bfe/gels-07-00233-g001.jpg

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