Wang Leah Liu, Seravalli Javier, Eaton Brett, Liu Yi, Holbrook Michael R, Lan Wen-Jian, Xiang Shi-Hua
Nebraska Center for Virology, School of Veterinary Medicine and Biomedical Sciences, University of Nebraska-Lincoln, Lincoln, NE 68583, USA.
Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, NE 68588, USA.
Mar Drugs. 2025 Jan 3;23(1):23. doi: 10.3390/md23010023.
Filoviruses, mainly consisting of the two genera of and , are enveloped negative-strand RNA viruses that can infect humans to cause severe hemorrhagic fevers and outbreaks with high mortality rates. However, we still do not have effective medicines for treating these diseases. To search for effective drugs, we have identified three marine indole alkaloids that exhibit potent activities against filovirus infection. Thus, it is suggested that marine indole alkaloids can be a valuable compound source for filovirus drug screening and development. Since marine indole alkaloids comprise a large diverse group of secondary metabolites, their biological properties would be helpful for pharmaceutical drug development to treat various filovirus infections.
丝状病毒主要由埃博拉病毒属和马尔堡病毒属这两个属组成，是有包膜的负链RNA病毒，可感染人类，导致严重出血热和高死亡率的疫情爆发。然而，我们仍然没有治疗这些疾病的有效药物。为了寻找有效药物，我们鉴定出了三种对丝状病毒感染具有强大活性的海洋吲哚生物碱。因此，有人提出海洋吲哚生物碱可能是丝状病毒药物筛选和开发的宝贵化合物来源。由于海洋吲哚生物碱包含一大类多样的次生代谢产物，它们的生物学特性将有助于开发治疗各种丝状病毒感染的药物。
